Is Triisotridecyl Trimellitate safe in cosmetics?
Triisotridecyl Trimellitate has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted. 1 toxicological study endpoint(s) are available in our database.
Triisotridecyl Trimellitate
Also known as: 1,2,4-Benzenetricarboxylic acid, 1,2,4-triisotridecyl ester, Triisotridecyl benzene-1,2,4-tricarboxylate, EINECS 276-594-2, Tris(isotridecyl)trimellitate
INCI: TRIISOTRIDECYL TRIMELLITATE
Triisotridecyl Trimellitate (CAS 72361-35-4) is a cosmetic cosmetic ingredient functioning as Skin conditioning agent. Reported NOAEL =300 mg/kg bw/day in Rat (ToxValDB_ECHA_IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 72361-35-4 →
Auto-generated CPSR Part A draft with source citations
Function
Skin conditioning agent
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
tris(11-methyldodecyl) benzene-1,2,4-tricarboxylate
InChIKey
IGQFKXMQIMEIJV-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
CIR concluded safe in present practices of use when formulated to be non-irritating (IJT 43(Suppl. 1):96S-120S, 2024)
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Triisotridecyl Trimellitate.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
1 study endpoint found for Triisotridecyl Trimellitate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =300 mg/kg bw/day | oral | Rat | short-term | ToxValDB_ECHA_IUCLID |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Endocrine Disruptors
Potential endocrine disrupting compound
Source: NORMAN Suspect List Exchange
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for Triisotridecyl Trimellitate.
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Triisotridecyl Trimellitate by CAS number or substance name.
Studies
1
Lowest NOAEL
300 mg/kg bw/day
Highest NOAEL
300 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Known Synonyms
1,2,4-Benzenetricarboxylic acid, 1,2,4-triisotridecyl ester
Triisotridecyl benzene-1,2,4-tricarboxylate
EINECS 276-594-2
Tris(isotridecyl)trimellitate
Chemical Function
Softener and conditioner
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Triisotridecyl Trimellitate allowed in the EU?
Triisotridecyl Trimellitate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Triisotridecyl Trimellitate do in cosmetics?
Triisotridecyl Trimellitate functions as: Skin conditioning agent. It is classified as a cosmetic ingredient in our database. CAS number: 72361-35-4.
What is the NOAEL for Triisotridecyl Trimellitate?
The NOAEL (No Observed Adverse Effect Level) for Triisotridecyl Trimellitate is =300 mg/kg bw/day based on a short-term study via oral route in Rat. Source: ToxValDB_ECHA_IUCLID.
Is Triisotridecyl Trimellitate used outside cosmetics?
Triisotridecyl Trimellitate also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
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MoS Calculator
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Heavy Metal Limits
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