Trimethyl Pentanyl Diisobutyrate
INCI: TRIMETHYL PENTANYL DIISOBUTYRATE
Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for Trimethyl Pentanyl Diisobutyrate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 0.10000000149 % | oral | dog | Subchronic | COSMOS_DB |
| LOAEL | 0.34999999404 % | oral | dog | Subchronic | COSMOS_DB |
| LOAEL | 0.10000000149 % | oral | rat | Subchronic | COSMOS_DB |
| LOAEL | 0.10000000149 % | oral | rat | Subchronic | COSMOS_DB |
| LOAEL | 0.10000000149 % | oral | rat | Subchronic | COSMOS_DB |
| LOEL | 750 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | >1 other | oral | rat | oral | REACH |
| NOAEL | >1 other | oral | dog | oral | REACH |
| NOAEL | >1 other | oral | rat | oral | REACH |
| NOEL | 30 other | oral | rat | oral | REACH |
Expert Verdict
Rare reports of mild skin irritation or allergic reactions with prolonged exposure; primarily nail care use — not broadly evaluated for leave-on skin products
Regulatory Flags
Frequently Asked Questions
Is Trimethyl Pentanyl Diisobutyrate safe in cosmetics?
Rare reports of mild skin irritation or allergic reactions with prolonged exposure; primarily nail care use — not broadly evaluated for leave-on skin products The EU classifies Trimethyl Pentanyl Diisobutyrate as "permitted". Safety rating: GOOD. 10 toxicological study endpoint(s) are available in our database.
Is Trimethyl Pentanyl Diisobutyrate allowed in the EU?
Trimethyl Pentanyl Diisobutyrate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Trimethyl Pentanyl Diisobutyrate do in cosmetics?
Trimethyl Pentanyl Diisobutyrate functions as: Film Forming, Plasticiser — enhances flexibility and durability of nail coatings. It is classified as a cosmetic ingredient in our database. CAS number: 6846-50-0.
What is the Margin of Safety for Trimethyl Pentanyl Diisobutyrate?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Trimethyl Pentanyl Diisobutyrate?
The NOAEL (No Observed Adverse Effect Level) for Trimethyl Pentanyl Diisobutyrate is 0.10000000149 % based on a Subchronic study via oral route in dog. A total of 10 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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Related Ingredients
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