Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for Triisopropyl Citrate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 0.10000000149 % | oral | dog | Subchronic | COSMOS_DB |
| LOAEL | 0.34999999404 % | oral | dog | Subchronic | COSMOS_DB |
| LOAEL | 0.10000000149 % | oral | rat | Subchronic | COSMOS_DB |
| LOAEL | 0.10000000149 % | oral | rat | Subchronic | COSMOS_DB |
| LOAEL | 0.10000000149 % | oral | rat | Subchronic | COSMOS_DB |
| LOEL | 750 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | >1 other | oral | rat | oral | REACH |
| NOAEL | >1 other | oral | dog | oral | REACH |
| NOAEL | >1 other | oral | rat | oral | REACH |
| NOEL | 30 other | oral | rat | oral | REACH |
Expert Verdict
None identified
Regulatory Flags
Frequently Asked Questions
Is Triisopropyl Citrate safe in cosmetics?
None identified The EU classifies Triisopropyl Citrate as "permitted". Safety rating: EXCELLENT. 10 toxicological study endpoint(s) are available in our database.
Is Triisopropyl Citrate allowed in the EU?
Triisopropyl Citrate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Triisopropyl Citrate do in cosmetics?
Triisopropyl Citrate functions as: Skin conditioning – emollient, plasticizer. It is classified as a cosmetic ingredient in our database. CAS number: 6846-50-0.
What is the Margin of Safety for Triisopropyl Citrate?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Triisopropyl Citrate?
The NOAEL (No Observed Adverse Effect Level) for Triisopropyl Citrate is 0.10000000149 % based on a Subchronic study via oral route in dog. A total of 10 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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Related Ingredients
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