Is Triisopropyl Citrate safe in cosmetics?
Triisopropyl Citrate has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted.
Excellent
Cosmetic Ingredient
Triisopropyl Citrate
Also known as: Propanoic acid, 2-methyl-, 2,2-dimethyl-1-(1-methylethyl)-1,3-propanediyl ester, BRN 1878083, EINECS 229-934-9, 2,2,4-Trimethylpentanediol-1,3-diisobutyrate, UNII-4KZA479DWQ
INCI: TRIISOPROPYL CITRATE
Triisopropyl Citrate (CAS 6846-50-0) is a cosmetic cosmetic ingredient functioning as Skin conditioning – emollient, plasticizer. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 6846-50-0 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Triisopropyl Citrate is classified GHS CMR hazard (H361, H412, H401) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Skin conditioning – emollient, plasticizer
Safety Rating
EXCELLENT
Chemistry & Identifiers
IUPAC Name
[2,2,4-trimethyl-3-(2-methylpropanoyloxy)pentyl] 2-methylpropanoate
InChIKey
OMVSWZDEEGIJJI-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted; covered under CIR citric acid/citrate esters safety assessment — safe as used
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Triisopropyl Citrate.
Calculate MoS for your specific formulation with the MoS Calculator.
Endocrine Disruptor Evidence (Expanded)
Cross-referenced EDC classifications, mechanism data, and dose-response evidence from EDLists, SIN List, and cosmetic-specific detail sources.
Suspected
Evidence: Limited
(2024)
Health effects: Yes
Affected pathways: Estrogenic
Regulatory framework: REACH
Source list: II
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (2)
Carcinogen Classification
No indication of carcinogenicity to humans (not listed by IARC).
Source: Toxin and Toxin Target Database (T3DB)
Skin Eye Respiratory Irritation
Eye irritation... rabbit... not irritating. | TXIB was slightly irritating to the skin of guinea pigs when the skin was exposed uncovered, and more irritating when covered. ... There was no evidence that TXIB was absorbed into the skin, but small skin flakes, desquamation, and little hair were visible after one week. After two weeks, desquamation and sparse hair persisted.
Source: Hazardous Substances Data Bank (HSDB)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Binder
Film former
Fragrance
Plasticizer
Processing aids not otherwise specified
Solvent
Regulatory List Membership (2)
IFRA Fragrance Transparency List
FDA Indirect Food Contact Additives
Expert Verdict
Expert safety assessment and concern-level summary for Triisopropyl Citrate.
Regulatory Flags
ifra_fragrance
Known Synonyms
Propanoic acid, 2-methyl-, 2,2-dimethyl-1-(1-methylethyl)-1,3-propanediyl ester
BRN 1878083
EINECS 229-934-9
2,2,4-Trimethylpentanediol-1,3-diisobutyrate
UNII-4KZA479DWQ
Chemical Function
Plasticizer
Binder
Regulatory Lists
Indirect additives food contact (10/2018)
inert_ingredient; non_food_use; Pesticides
air; Cons electronics mech appliances and machinery; detected; emissions; Europe
detected; Europe; Toys and children's products
detected; Europe; Toys and children's products
IFRA Transparency
detected; Europe; Other direct contact consumer goods
detected; Europe; Other direct contact consumer goods
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3183335
Frequently Asked Questions
Is Triisopropyl Citrate allowed in the EU?
Triisopropyl Citrate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Triisopropyl Citrate do in cosmetics?
Triisopropyl Citrate functions as: Skin conditioning – emollient, plasticizer. It is classified as a cosmetic ingredient in our database. CAS number: 6846-50-0.
Is Triisopropyl Citrate used outside cosmetics?
Triisopropyl Citrate also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Triisopropyl Citrate have different safety status in cosmetics vs industrial chemicals?
Triisopropyl Citrate is classified GHS CMR hazard (H361, H412, H401) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Triisopropyl Citrate compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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