Tripeptide-1 Dimethylaminoethyl Ester

INCI: TRIPEPTIDE-1 DIMETHYLAMINOETHYL ESTER

CAS Number
Not publicly assigned (derivative of Tripeptide-1, CAS 72957-37-0)
Function
Skin conditioning agent — modified form of Tripeptide-1 (GHK) with enhanced delivery via dimethylaminoethyl ester modification
Safety Rating
GOOD

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Permitted for cosmetic use; parent compound Tripeptide-1 assessed safe by CIR

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Limited standalone toxicological data; safety profile largely inferred from parent peptide family; the dimethylaminoethyl ester moiety could theoretically affect skin pH locally

⚠️
Concern Level: Moderate

Frequently Asked Questions

Is Tripeptide-1 Dimethylaminoethyl Ester safe in cosmetics?

Limited standalone toxicological data; safety profile largely inferred from parent peptide family; the dimethylaminoethyl ester moiety could theoretically affect skin pH locally The EU classifies Tripeptide-1 Dimethylaminoethyl Ester as "permitted". Safety rating: GOOD.

Is Tripeptide-1 Dimethylaminoethyl Ester allowed in the EU?

Tripeptide-1 Dimethylaminoethyl Ester EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Tripeptide-1 Dimethylaminoethyl Ester do in cosmetics?

Tripeptide-1 Dimethylaminoethyl Ester functions as: Skin conditioning agent — modified form of Tripeptide-1 (GHK) with enhanced delivery via dimethylaminoethyl ester modification. It is classified as a cosmetic ingredient in our database. CAS number: Not publicly assigned (derivative of Tripeptide-1, CAS 72957-37-0).

What is the Margin of Safety for Tripeptide-1 Dimethylaminoethyl Ester?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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