Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
5 study endpoints found for Trisodium EDTA. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 500 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | >=940 mg/kg bw/day | oral | mouse | oral | REACH |
| NOAEL | 453 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | >=495 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 500 mg/kg bw/day | oral | - | oral | REACH |
Expert Verdict
Good safety profile generally considered safe for cosmetic use.
Frequently Asked Questions
Is Trisodium EDTA safe in cosmetics?
Good safety profile generally considered safe for cosmetic use. The EU classifies Trisodium EDTA as "permitted". Safety rating: GOOD. 5 toxicological study endpoint(s) are available in our database.
Is Trisodium EDTA allowed in the EU?
Trisodium EDTA EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Trisodium EDTA do in cosmetics?
Trisodium EDTA functions as: Chelating agent. It is classified as a Cosmetic Ingredient in our database. CAS number: 150-38-9.
What is the Margin of Safety for Trisodium EDTA?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Trisodium EDTA?
The NOAEL (No Observed Adverse Effect Level) for Trisodium EDTA is 500 mg/kg bw/day based on a oral study via oral route in rat. A total of 5 study endpoints are available. Source: REACH.
Compliance Tools
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Related Ingredients
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