Good Cosmetic Ingredient NOAEL Data

Tris(Tetramethylhydroxypiperidinol) Citrate

Also known as: UNII-7NW772I64Y

INCI: TRIS(TETRAMETHYLHYDROXYPIPERIDINOL) CITRATE

Tris(Tetramethylhydroxypiperidinol) Citrate (CAS 220410-74-2) is a cosmetic cosmetic ingredient functioning as Light Stabilizer (HALS – Hindered Amine Light Stabilizer); protects. Reported NOAEL =150 mg/kg bw/day in Rat (ToxValDB_ECHA_IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.

View industrial chemical safety profile for CAS 220410-74-2 →

Auto-generated CPSR Part A draft with source citations
Function
Light Stabilizer (HALS – Hindered Amine Light Stabilizer); protects formulations from photodegradation
Safety Rating
GOOD

Chemistry & Identifiers

Formula
C33H65N3O13
MW
711.9 g/mol
EC Number
429-370-5
PubChem CID
68574231
IUPAC Name
2-hydroxypropane-1,2,3-tricarboxylic acid;tris(1-hydroxy-2,2,6,6-tetramethylpiperidin-4-ol)
InChIKey
TXXNVPVRPSACBM-UHFFFAOYSA-N

Regulatory Status

EU EU Status permitted
US US Status permitted
US Notes Permitted; 388 formulations in 2020 VCRP data; CIR safety-assessed

For full compliance data across multiple jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety, dermal absorption, and sensitization profile summaries for Tris(Tetramethylhydroxypiperidinol) Citrate.

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

1 study endpoint found for Tris(Tetramethylhydroxypiperidinol) Citrate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL =150 mg/kg bw/day dermal Rat subchronic ToxValDB_ECHA_IUCLID

EU CLP Annex VI Harmonized Classification

Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.

Signal Word
Warning
Pictograms
Harmful / Irritant
Hazard Class and Category
Acute Tox. 4 *
Hazard Statements
  • H302 Harmful if swallowed

Inserted via ATP: ATP01

ECHA REACH Registration

European Chemicals Agency REACH dossier and Substances of Very High Concern listing.

Registration Type
Full
Tonnage Band
1 - 10 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)

Function Categories & List Membership

Cosmetic/Chemical Function Categories
Fragrance Stabilizing agent UV stabilizer
Regulatory List Membership (2)
IFRA Fragrance Transparency List Consumer Product Chemical

Expert Verdict

Expert safety assessment and concern-level summary for Tris(Tetramethylhydroxypiperidinol) Citrate.

Regulatory Flags

ifra_fragrance

NOAEL Studies Summary

View details ->

Public NOAEL study rows linked to Tris(Tetramethylhydroxypiperidinol) Citrate by CAS number or substance name.

Studies
1
Lowest NOAEL
150 mg/kg bw/day
Highest NOAEL
150 mg/kg bw/day
ToxValDB_ECHA_IUCLID

Known Synonyms

UNII-7NW772I64Y

Chemical Function

UV stabilizer Stabilizing agent Fragrance

Regulatory Lists

IFRA Transparency consumer_product

Australian Status

AICIS status: listed_with_terms

Specific information requirements: Obligations to provide information apply. You must tell us within 28 days if the circumstances of your importation or manufacture (introduction) are different to those in our assessment.

Frequently Asked Questions

Is Tris(Tetramethylhydroxypiperidinol) Citrate safe in cosmetics?

Tris(Tetramethylhydroxypiperidinol) Citrate has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted. 1 toxicological study endpoint(s) are available in our database.

Is Tris(Tetramethylhydroxypiperidinol) Citrate allowed in the EU?

Tris(Tetramethylhydroxypiperidinol) Citrate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Tris(Tetramethylhydroxypiperidinol) Citrate do in cosmetics?

Tris(Tetramethylhydroxypiperidinol) Citrate functions as: Light Stabilizer (HALS – Hindered Amine Light Stabilizer); protects formulations from photodegradation. It is classified as a cosmetic ingredient in our database. CAS number: 220410-74-2.

What is the NOAEL for Tris(Tetramethylhydroxypiperidinol) Citrate?

The NOAEL (No Observed Adverse Effect Level) for Tris(Tetramethylhydroxypiperidinol) Citrate is =150 mg/kg bw/day based on a subchronic study via dermal route in Rat. Source: ToxValDB_ECHA_IUCLID.

Is Tris(Tetramethylhydroxypiperidinol) Citrate used outside cosmetics?

Tris(Tetramethylhydroxypiperidinol) Citrate also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.

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