Is TRIS(TETRAMETHYLHYDROXYPIPERIDINOL)CITRATE safe in cosmetics?
TRIS(TETRAMETHYLHYDROXYPIPERIDINOL)CITRATE has a safety rating of "GOOD" in our database. EU status: permitted. 1 toxicological study endpoint(s) are available in our database.
TRIS(TETRAMETHYLHYDROXYPIPERIDINOL)CITRATE
Also known as: UNII-7NW772I64Y
TRIS(TETRAMETHYLHYDROXYPIPERIDINOL)CITRATE (CAS 220410-74-2) is a cosmetic cosmetic ingredient functioning as Light Stabilizer. Reported NOAEL =150 mg/kg bw/day in Rat (ToxValDB_ECHA_IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 220410-74-2 →
Auto-generated CPSR Part A draft with source citations
Function
Light Stabilizer
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
2-hydroxypropane-1,2,3-tricarboxylic acid;tris(1-hydroxy-2,2,6,6-tetramethylpiperidin-4-ol)
InChIKey
TXXNVPVRPSACBM-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
Not specifically regulated
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Toxicological Studies
1 study endpoint found for TRIS(TETRAMETHYLHYDROXYPIPERIDINOL)CITRATE. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =150 mg/kg bw/day | dermal | Rat | subchronic | ToxValDB_ECHA_IUCLID |
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Warning
Pictograms
Harmful / Irritant
Hazard Class and Category
Acute Tox. 4 *
Hazard Statements
- H302 Harmful if swallowed
Inserted via ATP: ATP01
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1 - 10 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Fragrance
Stabilizing agent
UV stabilizer
Regulatory List Membership (2)
IFRA Fragrance Transparency List
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for TRIS(TETRAMETHYLHYDROXYPIPERIDINOL)CITRATE.
Regulatory Flags
cosing-sourced
eu-permitted
needs-enrichment
ifra_fragrance
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to TRIS(TETRAMETHYLHYDROXYPIPERIDINOL)CITRATE by CAS number or substance name.
Studies
1
Lowest NOAEL
150 mg/kg bw/day
Highest NOAEL
150 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Known Synonyms
UNII-7NW772I64Y
Chemical Function
UV stabilizer
Stabilizing agent
Fragrance
Regulatory Lists
IFRA Transparency
consumer_product
Australian Status
AICIS status: listed_with_terms
Specific information requirements: Obligations to provide information apply. You must tell us within 28 days if the circumstances of your importation or manufacture (introduction) are different to those in our assessment.
Frequently Asked Questions
Is TRIS(TETRAMETHYLHYDROXYPIPERIDINOL)CITRATE allowed in the EU?
TRIS(TETRAMETHYLHYDROXYPIPERIDINOL)CITRATE EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does TRIS(TETRAMETHYLHYDROXYPIPERIDINOL)CITRATE do in cosmetics?
TRIS(TETRAMETHYLHYDROXYPIPERIDINOL)CITRATE functions as: Light Stabilizer. It is classified as a cosmetic ingredient in our database. CAS number: 220410-74-2.
What is the NOAEL for TRIS(TETRAMETHYLHYDROXYPIPERIDINOL)CITRATE?
The NOAEL (No Observed Adverse Effect Level) for TRIS(TETRAMETHYLHYDROXYPIPERIDINOL)CITRATE is =150 mg/kg bw/day based on a subchronic study via dermal route in Rat. Source: ToxValDB_ECHA_IUCLID.
Is TRIS(TETRAMETHYLHYDROXYPIPERIDINOL)CITRATE used outside cosmetics?
TRIS(TETRAMETHYLHYDROXYPIPERIDINOL)CITRATE also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
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MoS Calculator
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