Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
1 study endpoint found for Trypsin. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | >=3420 other | oral | rat | oral | REACH |
Expert Verdict
Proteolytic activity can cause irritation on compromised/sensitive skin; concentration and pH must be tightly controlled; animal-origin (typically porcine pancreas) — vegan/halal/kosher compliance issue; potential respiratory sensitizer in manufacturing environments
Regulatory Flags
Frequently Asked Questions
Is Trypsin safe in cosmetics?
Proteolytic activity can cause irritation on compromised/sensitive skin; concentration and pH must be tightly controlled; animal-origin (typically porcine pancreas) — vegan/halal/kosher compliance issue; potential respiratory sensitizer in manufacturing environments The EU classifies Trypsin as "permitted". Safety rating: MODERATE. 1 toxicological study endpoint(s) are available in our database.
Is Trypsin allowed in the EU?
Trypsin EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Trypsin do in cosmetics?
Trypsin functions as: Skin Conditioning (enzymatic exfoliation/keratolytic). It is classified as a cosmetic ingredient in our database. CAS number: 9002-07-7.
What is the Margin of Safety for Trypsin?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Trypsin?
The NOAEL (No Observed Adverse Effect Level) for Trypsin is >=3420 other based on a oral study via oral route in rat. Source: REACH.
Compliance Tools
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Related Ingredients
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