NOAEL Studies
Fragrance
Vanillin NOAEL Studies
INCI: VANILLIN
CAS: 121-33-5
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
COSMOS_DB 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| COSMOS_DB | NOAEL | 100 | mg/kg bw/day | dog | oral | 186 day | Chronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 437 | mg/kg bw/day | rat | oral | 182 day | Chronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 500 | mg/kg bw/day | rat | oral | 252 day | Chronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 1000 | mg/kg bw/day | rat | oral | 730 day | Chronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip 21 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 250 | mg/kg bw/day | rat | oral: gavage | - | developmental toxicity | dossier=a2f2db22-6b9f-407d-b908-4cd97498d414.i6z; document=cff2366a-893a-48a6-ab76-a375205495b6_a2f2db22-6b9f-407d-b908-4cd97498d414.i6d; document_key=cff2366a-893a-48a6-ab76-a375205495b6/a2f2db22-6b9f-407d-b908-4cd97498d414; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1990; basis=other:; key_result=false; entry_uuid=8e3bdfe4-6cba-45b0-898a-1a2c80ff3095 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 750 | mg/kg bw/day | mouse | - | - | carcinogenicity, other | dossier=a2f2db22-6b9f-407d-b908-4cd97498d414.i6z; document=3326f12b-0645-49d5-bb39-f598b8c69b9f_a2f2db22-6b9f-407d-b908-4cd97498d414.i6d; document_key=3326f12b-0645-49d5-bb39-f598b8c69b9f/a2f2db22-6b9f-407d-b908-4cd97498d414; document_subtype=Carcinogenicity; literature=Name=Unnamed; ReferenceYear=1991; basis=histopathology: neoplastic; key_result=false; entry_uuid=be9e5ab2-14f2-403e-9fa1-529c1ee3fdf2 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | >=50 | mg/kg bw/day | mouse | intraperitoneal | - | developmental toxicity | dossier=a2f2db22-6b9f-407d-b908-4cd97498d414.i6z; document=6eb1a492-7121-4f21-bf4e-8c4c0c734360_a2f2db22-6b9f-407d-b908-4cd97498d414.i6d; document_key=6eb1a492-7121-4f21-bf4e-8c4c0c734360/a2f2db22-6b9f-407d-b908-4cd97498d414; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1988; basis=body weight and weight gain; key_result=false; entry_uuid=cf78ff51-75c9-47bb-b9bf-2ae72244e0fc |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | >300 | mg/kg bw/day | rat | other: | - | sub-chronic toxicity: oral | dossier=a2f2db22-6b9f-407d-b908-4cd97498d414.i6z; document=29f1db2f-6e76-4715-9cbf-cff12ce2c1c6_a2f2db22-6b9f-407d-b908-4cd97498d414.i6d; document_key=29f1db2f-6e76-4715-9cbf-cff12ce2c1c6/a2f2db22-6b9f-407d-b908-4cd97498d414; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1940; basis=other:; key_result=false; entry_uuid=e05b6d35-79f9-43c7-a525-b91e0d7b3659 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | >20 | mg/kg bw/day | rat | other: | - | sub-chronic toxicity: oral | dossier=a2f2db22-6b9f-407d-b908-4cd97498d414.i6z; document=29f1db2f-6e76-4715-9cbf-cff12ce2c1c6_a2f2db22-6b9f-407d-b908-4cd97498d414.i6d; document_key=29f1db2f-6e76-4715-9cbf-cff12ce2c1c6/a2f2db22-6b9f-407d-b908-4cd97498d414; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1940; basis=other:; key_result=false; entry_uuid=71ba72a3-58d4-4b09-9119-118c17cb6ed8 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 64 | mg/kg bw/day | rat | other: | - | sub-chronic toxicity: oral | dossier=a2f2db22-6b9f-407d-b908-4cd97498d414.i6z; document=29f1db2f-6e76-4715-9cbf-cff12ce2c1c6_a2f2db22-6b9f-407d-b908-4cd97498d414.i6d; document_key=29f1db2f-6e76-4715-9cbf-cff12ce2c1c6/a2f2db22-6b9f-407d-b908-4cd97498d414; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1940; basis=other:; key_result=false; entry_uuid=aa9e578e-fa55-41af-9937-23d512054795 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 250 | mg/kg bw/day | rat | oral: gavage | - | developmental toxicity | dossier=a2f2db22-6b9f-407d-b908-4cd97498d414.i6z; document=cff2366a-893a-48a6-ab76-a375205495b6_a2f2db22-6b9f-407d-b908-4cd97498d414.i6d; document_key=cff2366a-893a-48a6-ab76-a375205495b6/a2f2db22-6b9f-407d-b908-4cd97498d414; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1990; basis=other:; key_result=false; entry_uuid=8e3bdfe4-6cba-45b0-898a-1a2c80ff3095 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 750 | mg/kg bw/day | mouse | - | - | carcinogenicity, other | dossier=a2f2db22-6b9f-407d-b908-4cd97498d414.i6z; document=3326f12b-0645-49d5-bb39-f598b8c69b9f_a2f2db22-6b9f-407d-b908-4cd97498d414.i6d; document_key=3326f12b-0645-49d5-bb39-f598b8c69b9f/a2f2db22-6b9f-407d-b908-4cd97498d414; document_subtype=Carcinogenicity; literature=Name=Unnamed; ReferenceYear=1991; basis=histopathology: neoplastic; key_result=false; entry_uuid=be9e5ab2-14f2-403e-9fa1-529c1ee3fdf2 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | >=50 | mg/kg bw/day | mouse | intraperitoneal | - | developmental toxicity | dossier=a2f2db22-6b9f-407d-b908-4cd97498d414.i6z; document=6eb1a492-7121-4f21-bf4e-8c4c0c734360_a2f2db22-6b9f-407d-b908-4cd97498d414.i6d; document_key=6eb1a492-7121-4f21-bf4e-8c4c0c734360/a2f2db22-6b9f-407d-b908-4cd97498d414; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1988; basis=body weight and weight gain; key_result=false; entry_uuid=cf78ff51-75c9-47bb-b9bf-2ae72244e0fc |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | >300 | mg/kg bw/day | rat | other: | - | sub-chronic toxicity: oral | dossier=a2f2db22-6b9f-407d-b908-4cd97498d414.i6z; document=29f1db2f-6e76-4715-9cbf-cff12ce2c1c6_a2f2db22-6b9f-407d-b908-4cd97498d414.i6d; document_key=29f1db2f-6e76-4715-9cbf-cff12ce2c1c6/a2f2db22-6b9f-407d-b908-4cd97498d414; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1940; basis=other:; key_result=false; entry_uuid=e05b6d35-79f9-43c7-a525-b91e0d7b3659 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | >20 | mg/kg bw/day | rat | other: | - | sub-chronic toxicity: oral | dossier=a2f2db22-6b9f-407d-b908-4cd97498d414.i6z; document=29f1db2f-6e76-4715-9cbf-cff12ce2c1c6_a2f2db22-6b9f-407d-b908-4cd97498d414.i6d; document_key=29f1db2f-6e76-4715-9cbf-cff12ce2c1c6/a2f2db22-6b9f-407d-b908-4cd97498d414; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1940; basis=other:; key_result=false; entry_uuid=71ba72a3-58d4-4b09-9119-118c17cb6ed8 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 64 | mg/kg bw/day | rat | other: | - | sub-chronic toxicity: oral | dossier=a2f2db22-6b9f-407d-b908-4cd97498d414.i6z; document=29f1db2f-6e76-4715-9cbf-cff12ce2c1c6_a2f2db22-6b9f-407d-b908-4cd97498d414.i6d; document_key=29f1db2f-6e76-4715-9cbf-cff12ce2c1c6/a2f2db22-6b9f-407d-b908-4cd97498d414; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1940; basis=other:; key_result=false; entry_uuid=aa9e578e-fa55-41af-9937-23d512054795 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 250 | mg/kg bw/day | rat | oral: gavage | - | developmental toxicity | dossier=a2f2db22-6b9f-407d-b908-4cd97498d414.i6z; document=cff2366a-893a-48a6-ab76-a375205495b6_a2f2db22-6b9f-407d-b908-4cd97498d414.i6d; document_key=cff2366a-893a-48a6-ab76-a375205495b6/a2f2db22-6b9f-407d-b908-4cd97498d414; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1990; basis=other:; key_result=false; entry_uuid=8e3bdfe4-6cba-45b0-898a-1a2c80ff3095 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 750 | mg/kg bw/day | mouse | - | - | carcinogenicity, other | dossier=a2f2db22-6b9f-407d-b908-4cd97498d414.i6z; document=3326f12b-0645-49d5-bb39-f598b8c69b9f_a2f2db22-6b9f-407d-b908-4cd97498d414.i6d; document_key=3326f12b-0645-49d5-bb39-f598b8c69b9f/a2f2db22-6b9f-407d-b908-4cd97498d414; document_subtype=Carcinogenicity; literature=Name=Unnamed; ReferenceYear=1991; basis=histopathology: neoplastic; key_result=false; entry_uuid=be9e5ab2-14f2-403e-9fa1-529c1ee3fdf2 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | >=50 | mg/kg bw/day | mouse | intraperitoneal | - | developmental toxicity | dossier=a2f2db22-6b9f-407d-b908-4cd97498d414.i6z; document=6eb1a492-7121-4f21-bf4e-8c4c0c734360_a2f2db22-6b9f-407d-b908-4cd97498d414.i6d; document_key=6eb1a492-7121-4f21-bf4e-8c4c0c734360/a2f2db22-6b9f-407d-b908-4cd97498d414; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1988; basis=body weight and weight gain; key_result=false; entry_uuid=cf78ff51-75c9-47bb-b9bf-2ae72244e0fc |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | >300 | mg/kg bw/day | rat | other: | - | sub-chronic toxicity: oral | dossier=a2f2db22-6b9f-407d-b908-4cd97498d414.i6z; document=29f1db2f-6e76-4715-9cbf-cff12ce2c1c6_a2f2db22-6b9f-407d-b908-4cd97498d414.i6d; document_key=29f1db2f-6e76-4715-9cbf-cff12ce2c1c6/a2f2db22-6b9f-407d-b908-4cd97498d414; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1940; basis=other:; key_result=false; entry_uuid=e05b6d35-79f9-43c7-a525-b91e0d7b3659 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | >20 | mg/kg bw/day | rat | other: | - | sub-chronic toxicity: oral | dossier=a2f2db22-6b9f-407d-b908-4cd97498d414.i6z; document=29f1db2f-6e76-4715-9cbf-cff12ce2c1c6_a2f2db22-6b9f-407d-b908-4cd97498d414.i6d; document_key=29f1db2f-6e76-4715-9cbf-cff12ce2c1c6/a2f2db22-6b9f-407d-b908-4cd97498d414; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1940; basis=other:; key_result=false; entry_uuid=71ba72a3-58d4-4b09-9119-118c17cb6ed8 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 64 | mg/kg bw/day | rat | other: | - | sub-chronic toxicity: oral | dossier=a2f2db22-6b9f-407d-b908-4cd97498d414.i6z; document=29f1db2f-6e76-4715-9cbf-cff12ce2c1c6_a2f2db22-6b9f-407d-b908-4cd97498d414.i6d; document_key=29f1db2f-6e76-4715-9cbf-cff12ce2c1c6/a2f2db22-6b9f-407d-b908-4cd97498d414; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1940; basis=other:; key_result=false; entry_uuid=aa9e578e-fa55-41af-9937-23d512054795 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOEL | 500 | mg/kg bw/day | rat | oral: gavage | - | developmental toxicity | dossier=a2f2db22-6b9f-407d-b908-4cd97498d414.i6z; document=cff2366a-893a-48a6-ab76-a375205495b6_a2f2db22-6b9f-407d-b908-4cd97498d414.i6d; document_key=cff2366a-893a-48a6-ab76-a375205495b6/a2f2db22-6b9f-407d-b908-4cd97498d414; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1990; basis=other:; key_result=false; entry_uuid=cfdbd521-16e1-4f69-a226-9d6460ec3269 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOEL | 500 | mg/kg bw/day | rat | oral: gavage | - | developmental toxicity | dossier=a2f2db22-6b9f-407d-b908-4cd97498d414.i6z; document=cff2366a-893a-48a6-ab76-a375205495b6_a2f2db22-6b9f-407d-b908-4cd97498d414.i6d; document_key=cff2366a-893a-48a6-ab76-a375205495b6/a2f2db22-6b9f-407d-b908-4cd97498d414; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1990; basis=other:; key_result=false; entry_uuid=cfdbd521-16e1-4f69-a226-9d6460ec3269 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOEL | 500 | mg/kg bw/day | rat | oral: gavage | - | developmental toxicity | dossier=a2f2db22-6b9f-407d-b908-4cd97498d414.i6z; document=cff2366a-893a-48a6-ab76-a375205495b6_a2f2db22-6b9f-407d-b908-4cd97498d414.i6d; document_key=cff2366a-893a-48a6-ab76-a375205495b6/a2f2db22-6b9f-407d-b908-4cd97498d414; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1990; basis=other:; key_result=false; entry_uuid=cfdbd521-16e1-4f69-a226-9d6460ec3269 |
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx | NOAEL | =1000 | mg/kg bw/day | Rat | - | 730 days | chronic/long term toxicity | EFSA AFC - 2008 - OutputID 2243 - Flavouring Group Evaluation 52 (FGE.52): Consideration of hydroxy- and alkoxy substituted benzyl derivatives evaluated by JECFA (57th meeting) structurally related to benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters evaluated by EFSA in FGE.20 (2005) (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - doi:10.2903/j.efsa.2008.637 |
| EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx | NOAEL | =400 | mg/kg bw/day | Rat | oral: gavage | 91 days | subchronic | EFSA FEEDAP - 2012 - OutputID 607 - no adverse effect observed at single/highest dose - Scientific Opinion on the safety and efficacy of benzyl alcohols, aldehydes, acids, esters and acetals (chemical group 23) when used as flavourings for all animal species - doi:10.2903/j.efsa.2012.2785 |
| EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx | NOAEL | =1000 | mg/kg bw/day | Rat | - | 730 days | chronic/long term toxicity | EFSA AFC - 2008 - OutputID 2243 - Flavouring Group Evaluation 52 (FGE.52): Consideration of hydroxy- and alkoxy substituted benzyl derivatives evaluated by JECFA (57th meeting) structurally related to benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters evaluated by EFSA in FGE.20 (2005) (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - doi:10.2903/j.efsa.2008.637 |
| EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx | NOAEL | =400 | mg/kg bw/day | Rat | oral: gavage | 91 days | subchronic | EFSA FEEDAP - 2012 - OutputID 607 - no adverse effect observed at single/highest dose - Scientific Opinion on the safety and efficacy of benzyl alcohols, aldehydes, acids, esters and acetals (chemical group 23) when used as flavourings for all animal species - doi:10.2903/j.efsa.2012.2785 |
EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx | ADI | =10 | mg/kg bw/day | Consumers | - | - | ADI | EFSA ANS - 2018 - OutputID 3013 - Consumers - Safety of orthosilicic acid-vanillin complex (OSA-VC) as a novel food ingredient to be used in food supplements as a source of silicon and bioavailability of silicon from the source - doi:10.2903/j.efsa.2018.5086 |
| EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx | ADI | =10 | mg/kg bw/day | Consumers | - | - | ADI | EFSA ANS - 2018 - OutputID 3013 - Consumers - Safety of orthosilicic acid-vanillin complex (OSA-VC) as a novel food ingredient to be used in food supplements as a source of silicon and bioavailability of silicon from the source - doi:10.2903/j.efsa.2018.5086 |
NTP_ICE_acute_oral 7 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_acute_oral | LD50 | =1580 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_1698; row=570; data_type=In Vivo; mixture=Chemical; chemical_name=4-Hydroxy-3-methoxybenzaldehyde; preferred_name=4-Hydroxy-3-methoxybenzaldehyde; dtxsid=DTXSID0021969; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021969; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID0021969; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | =2000 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | record_id=acute_oral_1699; row=571; data_type=In Vivo; mixture=Chemical; chemical_name=4-Hydroxy-3-methoxybenzaldehyde; preferred_name=4-Hydroxy-3-methoxybenzaldehyde; dtxsid=DTXSID0021969; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021969; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID0021969; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | =2800 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_1701; row=575; data_type=In Vivo; mixture=Chemical; chemical_name=4-Hydroxy-3-methoxybenzaldehyde; preferred_name=4-Hydroxy-3-methoxybenzaldehyde; dtxsid=DTXSID0021969; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021969; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID0021969; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | =3300 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | ECHA ChemProp (undated); record_id=acute_oral_1633; row=572; data_type=In Vivo; mixture=Chemical; chemical_name=4-Hydroxy-3-methoxybenzaldehyde; preferred_name=4-Hydroxy-3-methoxybenzaldehyde; dtxsid=DTXSID0021969; url=https://echa.europa.eu/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021969; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID0021969; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | =3830 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | ECHA ChemProp (undated); record_id=acute_oral_1635; row=573; data_type=In Vivo; mixture=Chemical; chemical_name=4-Hydroxy-3-methoxybenzaldehyde; preferred_name=4-Hydroxy-3-methoxybenzaldehyde; dtxsid=DTXSID0021969; url=https://echa.europa.eu/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021969; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID0021969; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | =3925 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | ECHA ChemProp (undated); record_id=acute_oral_1636; row=576; data_type=In Vivo; mixture=Chemical; chemical_name=4-Hydroxy-3-methoxybenzaldehyde; preferred_name=4-Hydroxy-3-methoxybenzaldehyde; dtxsid=DTXSID0021969; url=https://echa.europa.eu/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021969; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID0021969; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | <3978 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | record_id=acute_oral_1638; row=574; data_type=In Vivo; mixture=Chemical; chemical_name=4-Hydroxy-3-methoxybenzaldehyde; preferred_name=4-Hydroxy-3-methoxybenzaldehyde; dtxsid=DTXSID0021969; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021969; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID0021969; source_file=acute_oral.xlsx |
NTP_ICE_adme_parameters 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_adme_parameters | Clint | 234 | uL/min/10^6 cells | Human | - | - | Measured; httk, Human Hepatic Intrinsic Clearance | sheet=Data; excel_row=136; Record_ID=adme_parameters_895; Data_Type=Measured; DTXSID=DTXSID0021969; Assay=httk, Human Hepatic Intrinsic Clearance; Endpoint=Clint; Response=234.0; Response_Unit=ul/min/10^6 cells; Species=Human; Reference=httk2.3.1, Wambaugh 2019; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021969; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021969 |
| NTP_ICE_adme_parameters | Fu | 0.322 | fraction | Human | - | - | Measured; httk, Human Plasma Fraction Unbound | sheet=Data; excel_row=137; Record_ID=adme_parameters_895; Data_Type=Measured; DTXSID=DTXSID0021969; Assay=httk, Human Plasma Fraction Unbound; Endpoint=Fu; Response=0.322; Response_Unit=Unitless Fraction; Species=Human; Reference=httk2.3.1, Wambaugh 2019; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021969; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021969 |
NTP_ICE_endocrine 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_endocrine | Model Score | 0 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=3916; RecordID=ARPathway2016_686; DatasetName=ARPathway2016; DTXSID=DTXSID0021969; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021969; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021969 |
NTP_ICE_skin_sensitization 29 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_skin_sensitization | CD86, EC150 | 49.9 | ug/mL | - | Dermal | - | In Vitro; CE_USENSE2018; U-SENS | sheet=Data_invitro; excel_row=8640; Record_ID=skin_sensitization_invitro_2389; Data_Type=In Vitro; Internal_Data_Source=CE_USENSE2018; Mixture=Chemical; DTXSID=DTXSID0021969; Assay=U-SENS; Endpoint=CD86, EC150; Reported_Response=49.9; Reported_Response_Unit=ug/mL; Response=49.9; Response_Unit=ug/mL; Reference=Piroird et al. 2015; 25820135; 10.1016/j.tiv.2015.03.009; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021969; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021969 |
| NTP_ICE_skin_sensitization | CD86, EC150 | 104.999 | ug/mL | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; U-SENS | sheet=Data_invitro; excel_row=8167; Record_ID=skin_sensitization_invitro_2190; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID0021969; Assay=U-SENS; Endpoint=CD86, EC150; Reported_Response=690.1084456; Reported_Response_Unit=uM; Conversion_Factor_Value=152.149; Conversion_Factor_Source=EPA Dashboard; Converted_Response=104.999; Converted_Response_Unit=ug/mL; Response=104.999; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021969; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021969 |
| NTP_ICE_skin_sensitization | CD86, EC150 | 301.17 | ug/mL | - | Dermal | - | In Vitro; hCLAT2015; h-CLAT | sheet=Data_invitro; excel_row=3414; Record_ID=skin_sensitization_invitro_791; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID0021969; Assay=h-CLAT; Endpoint=CD86, EC150; Reported_Response=301.17180000000002; Reported_Response_Unit=ug/mL; Response=301.17; Response_Unit=ug/mL; Reference=Sakaguchi et al. 2010; 20510347; 10.1016/j.tiv.2010.05.012|h-CLAT RingTrial EC values for NICEATM (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021969; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021969 |
| NTP_ICE_skin_sensitization | CV70 | >200 | ug/mL | - | Dermal | - | In Vitro; CE_USENSE2018; U-SENS | sheet=Data_invitro; excel_row=8638; Record_ID=skin_sensitization_invitro_2389; Data_Type=In Vitro; Internal_Data_Source=CE_USENSE2018; Mixture=Chemical; DTXSID=DTXSID0021969; Assay=U-SENS; Endpoint=CV70; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=200; Reported_Response_Unit=ug/mL; Response=200; Response_Unit=ug/mL; Reference=Piroird et al. 2015; 25820135; 10.1016/j.tiv.2015.03.009; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021969; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021969 |
| NTP_ICE_skin_sensitization | CV75 | 394.7 | ug/mL | - | Dermal | - | In Vitro; hCLAT2015; h-CLAT | sheet=Data_invitro; excel_row=3400; Record_ID=skin_sensitization_invitro_787; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID0021969; Assay=h-CLAT; Endpoint=CV75; Reported_Response=394.7; Reported_Response_Unit=ug/mL; Response=394.7; Response_Unit=ug/mL; Reference=Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021969; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021969 |
| NTP_ICE_skin_sensitization | CV75 | 569 | ug/mL | - | Dermal | - | In Vitro; hCLAT2015; h-CLAT | sheet=Data_invitro; excel_row=3423; Record_ID=skin_sensitization_invitro_792; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID0021969; Assay=h-CLAT; Endpoint=CV75; Reported_Response=569; Reported_Response_Unit=ug/mL; Response=569; Response_Unit=ug/mL; Reference=Sakaguchi et al. 2010; 20510347; 10.1016/j.tiv.2010.05.012|h-CLAT RingTrial EC values for NICEATM (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021969; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021969 |
| NTP_ICE_skin_sensitization | CV75 | 650 | ug/mL | - | Dermal | - | In Vitro; CE_hCLAT2018; h-CLAT | sheet=Data_invitro; excel_row=2313; Record_ID=skin_sensitization_invitro_558; Data_Type=In Vitro; Internal_Data_Source=CE_hCLAT2018; Mixture=Chemical; DTXSID=DTXSID0021969; Assay=h-CLAT; Endpoint=CV75; Reported_Response=650; Reported_Response_Unit=ug/mL; Response=650; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021969; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021969 |
| NTP_ICE_skin_sensitization | CV75 | 670 | ug/mL | - | Dermal | - | In Vitro; hCLAT2015; h-CLAT | sheet=Data_invitro; excel_row=3435; Record_ID=skin_sensitization_invitro_795; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID0021969; Assay=h-CLAT; Endpoint=CV75; Reported_Response=670; Reported_Response_Unit=ug/mL; Response=670; Response_Unit=ug/mL; Reference=Sakaguchi et al. 2010; 20510347; 10.1016/j.tiv.2010.05.012|h-CLAT RingTrial EC values for NICEATM (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021969; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021969 |
| NTP_ICE_skin_sensitization | CV75 | 673 | ug/mL | - | Dermal | - | In Vitro; hCLAT2015; h-CLAT | sheet=Data_invitro; excel_row=3393; Record_ID=skin_sensitization_invitro_786; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID0021969; Assay=h-CLAT; Endpoint=CV75; Reported_Response=673; Reported_Response_Unit=ug/mL; Response=673; Response_Unit=ug/mL; Reference=Sakaguchi et al. 2010; 20510347; 10.1016/j.tiv.2010.05.012|h-CLAT RingTrial EC values for NICEATM (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021969; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021969 |
| NTP_ICE_skin_sensitization | CV75 | 791.5 | ug/mL | - | Dermal | - | In Vitro; hCLAT2015; h-CLAT | sheet=Data_invitro; excel_row=3408; Record_ID=skin_sensitization_invitro_789; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID0021969; Assay=h-CLAT; Endpoint=CV75; Reported_Response=791.5; Reported_Response_Unit=ug/mL; Response=791.5; Response_Unit=ug/mL; Reference=Sakaguchi et al. 2010; 20510347; 10.1016/j.tiv.2010.05.012|h-CLAT RingTrial EC values for NICEATM (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021969; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021969 |
| NTP_ICE_skin_sensitization | CV75 | 1364.7 | ug/mL | - | Dermal | - | In Vitro; hCLAT2015; h-CLAT | sheet=Data_invitro; excel_row=3431; Record_ID=skin_sensitization_invitro_794; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID0021969; Assay=h-CLAT; Endpoint=CV75; Reported_Response=1364.7; Reported_Response_Unit=ug/mL; Response=1364.7; Response_Unit=ug/mL; Reference=Sakaguchi et al. 2010; 20510347; 10.1016/j.tiv.2010.05.012|h-CLAT RingTrial EC values for NICEATM (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021969; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021969 |
| NTP_ICE_skin_sensitization | Depletion Cys | -1.3 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=1167; Record_ID=skin_sensitization_invitro_316; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID0021969; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=-1.3; Reported_Response_Unit=%; Response=-1.3; Response_Unit=%; Reference=Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021969; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021969 |
| NTP_ICE_skin_sensitization | Depletion Cys | 3.2 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=1184; Record_ID=skin_sensitization_invitro_320; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID0021969; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=3.2; Reported_Response_Unit=%; Response=3.2; Response_Unit=%; Reference=Gerberick et al. 2007; 17400584; 10.1093/toxsci/kfm064|Jaworska 2011; 23670904; 10.1002/jat.2869|Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021969; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021969 |
| NTP_ICE_skin_sensitization | Depletion Lys | -6.6 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=1182; Record_ID=skin_sensitization_invitro_320; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID0021969; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=-6.6; Reported_Response_Unit=%; Response=-6.6; Response_Unit=%; Reference=Gerberick et al. 2007; 17400584; 10.1093/toxsci/kfm064|Jaworska 2011; 23670904; 10.1002/jat.2869|Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021969; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021969 |
| NTP_ICE_skin_sensitization | Depletion Lys | 19.8 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=1166; Record_ID=skin_sensitization_invitro_316; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID0021969; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=19.8; Reported_Response_Unit=%; Response=19.8; Response_Unit=%; Reference=Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021969; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021969 |
| NTP_ICE_skin_sensitization | Depletion Lys + Cys | 1.6 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=1186; Record_ID=skin_sensitization_invitro_320; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID0021969; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=1.6; Reported_Response_Unit=%; Response=1.6; Response_Unit=%; Reference=Gerberick et al. 2007; 17400584; 10.1093/toxsci/kfm064|Jaworska 2011; 23670904; 10.1002/jat.2869|Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021969; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021969 |
| NTP_ICE_skin_sensitization | Depletion Lys + Cys | 9.25 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=1169; Record_ID=skin_sensitization_invitro_316; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID0021969; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=9.25; Reported_Response_Unit=%; Response=9.25; Response_Unit=%; Reference=Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021969; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021969 |
| NTP_ICE_skin_sensitization | EC1.5 | 83 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=4918; Record_ID=skin_sensitization_invitro_1138; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID0021969; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=83; Reported_Response_Unit=uM; Response=83; Response_Unit=uM; Reference=Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021969; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021969 |
| NTP_ICE_skin_sensitization | EC1.5 | >2000 | uM | - | Dermal | - | In Vitro; CE_KeratinoSense2018; KeratinoSens | sheet=Data_invitro; excel_row=4917; Record_ID=skin_sensitization_invitro_1139; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID0021969; Assay=KeratinoSens; Endpoint=EC1.5; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=2000; Reported_Response_Unit=uM; Response=2000; Response_Unit=uM; Reference=Natsch et al. 2013; 23576290; 10.1002/jat.2868|Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021969; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021969 |
| NTP_ICE_skin_sensitization | IC50 | >1650 | uM | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; LuSens | sheet=Data_invitro; excel_row=7635; Record_ID=skin_sensitization_invitro_1803; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID0021969; Assay=LuSens; Endpoint=IC50; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=1650; Reported_Response_Unit=uM; Response=1650; Response_Unit=uM; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021969; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021969 |
| NTP_ICE_skin_sensitization | IC50 | >2000 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=4924; Record_ID=skin_sensitization_invitro_1138; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID0021969; Assay=KeratinoSens; Endpoint=IC50; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=2000; Reported_Response_Unit=uM; Response=2000; Response_Unit=uM; Reference=Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021969; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021969 |
| NTP_ICE_skin_sensitization | Imax | 1.4 | ratio | - | Dermal | - | In Vitro; CE_KeratinoSense2018; KeratinoSens | sheet=Data_invitro; excel_row=4926; Record_ID=skin_sensitization_invitro_1139; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID0021969; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.4; Reported_Response_Unit=Unitless; Response=1.4; Response_Unit=Ratio; Reference=Natsch et al. 2013; 23576290; 10.1002/jat.2868|Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021969; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021969 |
| NTP_ICE_skin_sensitization | Imax | 1.478 | ratio | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; LuSens | sheet=Data_invitro; excel_row=7536; Record_ID=skin_sensitization_invitro_1803; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID0021969; Assay=LuSens; Endpoint=Imax; Reported_Response=1.477528149; Reported_Response_Unit=Unitless; Response=1.478; Response_Unit=Ratio; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021969; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021969 |
| NTP_ICE_skin_sensitization | Imax | 2.29 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=4928; Record_ID=skin_sensitization_invitro_1138; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID0021969; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=2.29; Reported_Response_Unit=Unitless; Response=2.29; Response_Unit=Ratio; Reference=Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021969; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021969 |
| NTP_ICE_skin_sensitization | Incidence of positive responses | 0 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=4247; Record_ID=skin_sensitization_invivo_1030; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=2.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID0021969; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Greif 1967; Not available; Not available|Opdyke 1977; Not available; 10.1016/0015-6264(77)90086-4|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021969; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021969 |
| NTP_ICE_skin_sensitization | Induction dose per skin area | 1241 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=4245; Record_ID=skin_sensitization_invivo_1030; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=2.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID0021969; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=1241; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Greif 1967; Not available; Not available|Opdyke 1977; Not available; 10.1016/0015-6264(77)90086-4|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021969; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021969 |
| NTP_ICE_skin_sensitization | Induction dose per skin area | 3240 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=4253; Record_ID=skin_sensitization_invivo_1032; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=5.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID0021969; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=3240; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1970: report to RIFM|Opdyke 1977; Not available; 10.1016/0015-6264(77)90086-4|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021969; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021969 |
| NTP_ICE_skin_sensitization | Relative reliability score | 2 | unitless | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=4251; Record_ID=skin_sensitization_invivo_1030; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=2.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID0021969; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=2; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Greif 1967; Not available; Not available|Opdyke 1977; Not available; 10.1016/0015-6264(77)90086-4|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021969; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021969 |
| NTP_ICE_skin_sensitization | Relative reliability score | 3 | unitless | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=4259; Record_ID=skin_sensitization_invivo_1032; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=5.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID0021969; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Kligman 1970: report to RIFM|Opdyke 1977; Not available; 10.1016/0015-6264(77)90086-4|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021969; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021969 |
ToxValDB_ECHA_IUCLID 7 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ECHA_IUCLID | NOAEL | >=78 | mg/kg bw/day | Rat | oral | chronic; 16 weeks | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae98e4b0a7c65d1ca146; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/10954/7/6/2?documentUUID=c7228af6-ae61-499a-a1bd-520f8b42037b; YEAR=2013; ORIGINAL_YEAR=2013; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15844475_15850539:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_bb38e53dd6ffef29cafd8bd7e6fa1d60 |
| ToxValDB_ECHA_IUCLID | NOAEL | =250 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac4ae4b0a7c65d1be5d6; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/10954/7/9/3?documentUUID=c7228af6-ae61-499a-a1bd-520f8b42037b; YEAR=2013; ORIGINAL_YEAR=2013; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15824120_15824121_15824122:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_63316b4f79e1a1bb8394263b0a4c22fa |
| ToxValDB_ECHA_IUCLID | NOAEL | =780 | mg/kg bw/day | Rat | oral | chronic; 16 weeks | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead05e4b0a7c65d1c21bd; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/33162/7/6/2?documentUUID=a2f2db22-6b9f-407d-b908-4cd97498d414; YEAR=2001; ORIGINAL_YEAR=2001; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15844475_15850539:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_f7b6ff6bec9411d1ea29a696521a74d5 |
| ToxValDB_ECHA_IUCLID | NOAEL | <=1000 | mg/kg bw/day | Rat | oral | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c9e9e4b0a7c65d21f487; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/26453/7/6/2?documentUUID=0594086a-c7c2-412e-8e9c-32c58c3bdeff; YEAR=1974; ORIGINAL_YEAR=1974; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15847135_15850122:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_c1225b74bfd0b432341e4f5dcbdb4f74 |
| ToxValDB_ECHA_IUCLID | NOAEL | >=1560 | mg/kg bw/day | Rat | oral | chronic; 2 years | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead05e4b0a7c65d1c21b9; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/33162/7/6/2?documentUUID=a2f2db22-6b9f-407d-b908-4cd97498d414; YEAR=2001; ORIGINAL_YEAR=2001; STUDY_GROUP=ECHA IUCLID:15850538:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_75b1ec384ab5453ac798dfd24b800c8f |
| ToxValDB_ECHA_IUCLID | NOAEL | >=3900 | mg/kg bw/day | Rat | oral | chronic; 1 years | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead05e4b0a7c65d1c21c0; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/33162/7/6/2?documentUUID=a2f2db22-6b9f-407d-b908-4cd97498d414; YEAR=2001; ORIGINAL_YEAR=2001; STUDY_GROUP=ECHA IUCLID:15850540:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_f60fa158f0c7cc462ed5ba48ae7a539a |
| ToxValDB_ECHA_IUCLID | NOEL | =500 | mg/kg bw/day | Rat | oral | - | developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d232e4b0a7c65d2320b2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/26453/7/9/3?documentUUID=0594086a-c7c2-412e-8e9c-32c58c3bdeff; YEAR=1974; ORIGINAL_YEAR=1974; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15824117_15824118_15824119:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_035c0f15f6f0610972dfff1308fa0055 |
ToxValDB_EFSA 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_EFSA | NOAEL | =400 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | LONG_REF=EFSA FEEDAP (2012). Scientific Opinion on the safety and efficacy of benzyl alcohols, aldehydes, acids, esters and acetals (chemical group 23) when used as flavourings for all animal species. doi:10.2903/j.efsa.2012.2785.; TITLE=Scientific Opinion on the safety and efficacy of benzyl alcohols, aldehydes, acids, esters and acetals (chemical group 23) when used as flavourings for all animal species; AUTHOR=EFSA FEEDAP; DOI=doi:10.2903/j.efsa.2012.2785; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2012; ORIGINAL_YEAR=2012; TOXICOLOGICAL_EFFECT=no effects; STUDY_GROUP=EFSA:15614197:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e57b5eb7e7a7ddc42797479eed280504 |
ToxValDB_WHO_JECFA_ADI 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_WHO_JECFA_ADI | ADI | <=10 | mg/kg | Human | oral | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/650b0223e4b0d99f5a8852ad; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://apps.who.int/food-additives-contaminants-jecfa-database/; SUBSOURCE_URL=https://apps.who.int/food-additives-contaminants-jecfa-database/Home/Chemical/3799; YEAR=2001; ORIGINAL_YEAR=2001; STUDY_GROUP=WHO JECFA ADI:15715636:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_fcaec86d2db9e9e9b9b3cdb2c7e7affd |
openFDA substances 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | CHI530446X | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C8H8O3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"CHI530446X"} |
| openFDA substances | FDA UNII substance identifier | CHI530446X | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C8H8O3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"CHI530446X"} |
| openFDA substances | FDA UNII substance identifier | CHI530446X | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C8H8O3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"CHI530446X"} |
| openFDA substances | FDA UNII substance identifier | CHI530446X | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C8H8O3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"CHI530446X"} |