Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for Vanillin. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 1000 mg/kg bw/day | oral | rat | Chronic | COSMOS_DB |
| NOAEL | 437 mg/kg bw/day | oral | rat | Chronic | COSMOS_DB |
| NOAEL | 100 mg/kg bw/day | oral | dog | Chronic | COSMOS_DB |
| NOAEL | 500 mg/kg bw/day | oral | rat | Chronic | COSMOS_DB |
| dose_tested | 1000 mg/kg bw/day | oral | rat | Chronic | COSMOS_DB |
| dose_tested | 437 mg/kg bw/day | oral | rat | Chronic | COSMOS_DB |
| dose_tested | 100 mg/kg bw/day | oral | dog | Chronic | COSMOS_DB |
| dose_tested | 500 mg/kg bw/day | oral | rat | Chronic | COSMOS_DB |
| NOAEL | 10000 ppm | oral | rat | oral | REACH |
| NOAEL | 10000 ppm | oral | rat | oral | REACH |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Sensitization Profile
Contact sensitization data for Vanillin based on clinical patch test studies and IFRA standards.
Source: EU 2023/1545; SCCS/1459/11
Expert Verdict
Vanillin (nature-identical synthetic) is the dominant commercial form of vanilla fragrance. Molecularly identical to natural vanilla-derived vanillin with the same allergen profile. EU Regulation 2023/1545 mandates labelling above 10 ppm (leave-on) or 100 ppm (rinse-off). Lignin-derived and ferulic acid routes offer improved natural origin credentials without molecular difference.
Regulatory Flags
Frequently Asked Questions
Is Vanillin safe in cosmetics?
Vanillin (nature-identical synthetic) is the dominant commercial form of vanilla fragrance. Molecularly identical to natural vanilla-derived vanillin with the same allergen profile. EU Regulation 2023/1545 mandates labelling above 10 ppm (leave-on) or 100 ppm (rinse-off). Lignin-derived and ferulic acid routes offer improved natural origin credentials without molecular difference. The EU classifies Vanillin as "restricted". Safety rating: GOOD. 10 toxicological study endpoint(s) are available in our database.
Is Vanillin allowed in the EU?
Vanillin EU regulatory status: restricted. Maximum allowed concentration: Labelling threshold: 10 ppm (leave-on) / 100 ppm (rinse-off) per EU Regulation 2023/1545. No concentration restriction in cosmetics.. This is based on EU Regulation 1223/2009 and its amendments.
What does Vanillin do in cosmetics?
Vanillin functions as: Fragrance ingredient; nature-identical aromatic aldehyde. Primary aromatic compound of natural vanilla produced synthetically from guaiacol (petrochemical route), lignin (paper industry byproduct), or ferulic acid (biotransformation from rice bran). Molecularly identical to vanilla-derived vanillin. Antioxidant secondary activity. Wide cosmetic use as fragrance, flavoring in oral care, and masking agent.. It is classified as a Fragrance in our database. CAS number: 121-33-5.
What is the Margin of Safety for Vanillin?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Vanillin?
The NOAEL (No Observed Adverse Effect Level) for Vanillin is 1000 mg/kg bw/day based on a Chronic study via oral route in rat. A total of 10 study endpoints are available. Source: COSMOS_DB.
Is Vanillin classified as hazardous under GHS?
Vanillin carries a GHS signal word of "WARNING". Hazard statements: May be harmful if swallowed Harmful to aquatic life. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.
Compliance Tools
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