What is the NOAEL for L-Histidine?
L-Histidine has 7 NOAEL studies in the database. The lowest reported value is 83.38 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
L-Histidine
Also known as: Histidine, L-, 8: PN: EP2878667 TABLE: 5 claimed sequence, (2S)-2-Amino-3-(1H-imidazol-5-yl)propanoic acid, 4-(2-Amino-2-carboxyethyl)imidazole, alpha-Amino-1H-imidazole-4-propionic acid, (S)- (+15 more)
CAS 71-00-1
L-Histidine (CAS 71-00-1) is a chemical substance. Key regulatory status: REACH registered, 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
7
SOURCE
chemical inventory jurisdictions
Regulatory lists
3
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
26 fields
Name
L-Histidine
CAS Number
71-00-1
DTXSID
DTXSID9023126
Molecular Formula
C6H9N3O2
InChI Key
HNDVDQJCIGZPNO-YFKPBYRVSA-N
Monoisotopic Mass
155.069477
Synonyms
Histidine, L-8: PN: EP2878667 TABLE: 5 claimed sequence(2S)-2-Amino-3-(1H-imidazol-5-yl)propanoic acid4-(2-Amino-2-carboxyethyl)imidazolealpha-Amino-1H-imidazole-4-propionic acid, (S)-alpha-Amino-4(or 5)-imidazolepropionic acidAnti-rheumaEINECS 200-745-3FEMA No. 3694S-Histidine1H-Imidazole-4-propanoic acid, alpha-amino-, (S)-Istidina
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
7 records
HumectantAnti-static agentSoftener and conditionerFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
3 records
| List | Keyword | Source |
|---|---|---|
| pharmaceutical | US International Trade Commission | CPCat |
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 7 of 7 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =83.38 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 4QD397987E | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 4QD397987E | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 4QD397987E | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 4QD397987E | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| >15000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| 5000 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
Showing 7 of 7 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Histidine | 200-745-3 | ECHA overview → |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
antioxidant
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
HISTIDINE
ChEMBL Phase
2
Adverse Events
2
Bioactivity
5
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include L-Histidine?
L-Histidine appears on 3 regulatory/inventory lists including pharmaceutical, Europe, food_additive; Substances Added to Food (formerly EAFUS) (2/2019). Source: EPA CPDat.
Is L-Histidine used in cosmetics?
Yes, L-Histidine is also indexed as a cosmetic ingredient under the name L-Histidine. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for L-Histidine come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is L-Histidine used outside industrial chemicals?
L-Histidine also appears in cosmetics, pharmaceutical, cannabis databases.