Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for L-Histidine. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 5000 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 5000 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 5000 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 5000 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 5000 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 5000 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 5000 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 5000 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 5000 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 5000 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
Expert Verdict
L-Histidine acts as a hydrogen-donating antioxidant that enhances ROS scavenging capacity and is structurally critical as the central residue of the GHK copper-carrier sequence. GRAS status and CIR safety classification with no regulatory restrictions.
Regulatory Flags
Frequently Asked Questions
Is L-Histidine safe in cosmetics?
L-Histidine acts as a hydrogen-donating antioxidant that enhances ROS scavenging capacity and is structurally critical as the central residue of the GHK copper-carrier sequence. GRAS status and CIR safety classification with no regulatory restrictions. The EU classifies L-Histidine as "permitted". Safety rating: EXCELLENT. 10 toxicological study endpoint(s) are available in our database.
Is L-Histidine allowed in the EU?
L-Histidine EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does L-Histidine do in cosmetics?
L-Histidine functions as: Semi-essential amino acid functioning as a hydrogen donor in ROS scavenging reactions, enhancing antioxidant capacity. Core residue in the GHK copper-carrier tripeptide sequence. Histidine's imidazole ring coordinates metal ions and participates in antioxidant hydrogen donation. Contributes to the free amino acid antioxidant pool in the skin's natural moisturizing environment.. It is classified as a Antioxidant in our database. CAS number: 71-00-1.
What is the Margin of Safety for L-Histidine?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for L-Histidine?
The NOAEL (No Observed Adverse Effect Level) for L-Histidine is 5000 mg/kg bw/day based on a Short Term Toxicity study via oral route in rat. A total of 10 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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Related Ingredients
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