Is L-Histidine safe in cosmetics?
L-Histidine has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted.
Excellent
Antioxidant
L-Histidine
INCI: HISTIDINE
L-Histidine (CAS 71-00-1) is a cosmetic antioxidant functioning as Semi-essential amino acid functioning as a hydrogen donor in ROS scavenging. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in pharmaceutical data.
View industrial chemical safety profile for CAS 71-00-1 →
Auto-generated CPSR Part A draft with source citations
Function
Semi-essential amino acid functioning as a hydrogen donor in ROS scavenging reactions, enhancing antioxidant capacity. Core residue in the GHK copper-carrier tripeptide sequence. Histidine's imidazole ring coordinates metal ions and participates in antioxidant hydrogen donation. Contributes to the free amino acid antioxidant pool in the skin's natural moisturizing environment.
Safety Rating
EXCELLENT
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
FDA GRAS status. CIR-assessed safe class for amino acids.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for L-Histidine.
Calculate MoS for your specific formulation with the MoS Calculator.
Expert Verdict
Expert safety assessment and concern-level summary for L-Histidine.
Regulatory Flags
gras-fda
cir-approved
antioxidant
ros-scavenging
ghk-component
fda_food_additive
jecfa_safe
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
HISTIDINE
ChEMBL ID
CHEMBL17962
Max Phase
2
Adverse Event Associations
2
Frequently Asked Questions
Is L-Histidine allowed in the EU?
L-Histidine EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does L-Histidine do in cosmetics?
L-Histidine functions as: Semi-essential amino acid functioning as a hydrogen donor in ROS scavenging reactions, enhancing antioxidant capacity. Core residue in the GHK copper-carrier tripeptide sequence. Histidine's imidazole ring coordinates metal ions and participates in antioxidant hydrogen donation. Contributes to the free amino acid antioxidant pool in the skin's natural moisturizing environment.. It is classified as a Antioxidant in our database. CAS number: 71-00-1.
Is L-Histidine used outside cosmetics?
L-Histidine also appears in pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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