What is the NOAEL for Piperine?
Piperine has 15 NOAEL studies in the database. The lowest reported value is U71XL721QK UNII. Source: openFDA substances.
NOAEL Data
Cosmetic Ingredient
Piperine
Also known as: Piperidine, 1-[(2E,4E)-5-(1,3-benzodioxol-5-yl)-1-oxo-2,4-pentadienyl]-, 1-(5-(1,3-Benzodioxol-5-yl)-1-oxo-2,4-pentadienyl)piperidine, (E,E)-, 1,3-Benzodioxol-5-yl-1-oxo-2,4-pentadienyl-piperine, EINECS 202-348-0, FEMA No. 2909 (+8 more)
CAS 94-62-2
Piperine (CAS 94-62-2) is a chemical substance. Key regulatory status: 23 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS.
Cross-Vertical Regulatory Divergence
Piperine is classified GHS Danger (H301) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
15
SOURCE
chemical inventory jurisdictions
Regulatory lists
23
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
19 fields
Name
Piperine
CAS Number
94-62-2
DTXSID
DTXSID3021805
Molecular Formula
C17H19NO3
InChI Key
MXXWOMGUGJBKIW-YPCIICBESA-N
Monoisotopic Mass
285.136493
Synonyms
Piperidine, 1-[(2E,4E)-5-(1,3-benzodioxol-5-yl)-1-oxo-2,4-pentadienyl]-1-(5-(1,3-Benzodioxol-5-yl)-1-oxo-2,4-pentadienyl)piperidine, (E,E)-1,3-Benzodioxol-5-yl-1-oxo-2,4-pentadienyl-piperineEINECS 202-348-0FEMA No. 2909Piperidine, 1-(5-(1,3-benzodioxol-5-yl)-1-oxo-2,4-pentadienyl)-, (E,E)-Piperoylpiperidine1-Piperoylpiperidine, (E,E)-UNII-U71XL721QK(E,E)-1-piperoylpiperidine1-[(2E,4E)-5-(1,3-benzodioxol-5-yl)-1-oxo-2,4-pentadienyl]piperidine1-[(2E,4E)-5-(1,3-benzodioxol-5-yl)-2,4-pentadienoyl]piperidine
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
4 records
FragranceFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
23 records
| List | Keyword | Source |
|---|---|---|
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | California Department of Pesticide Regulation | State of California |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| IFRA Transparency | IFRA | IFRA |
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| Canada; pharmaceutical | DrugBank | DrugBank |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 15 of 15 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| U71XL721QK | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| U71XL721QK | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| U71XL721QK | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| U71XL721QK | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =514 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| 1.12 | mg/kg bw/day | NOAEL | oral | mouse | COSMOS_DB |
| 5 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| =5 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_EFSA |
| =5 | mg/kg bw/day | NOAEL | oral: feed | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| =5 | mg/kg bw/day | NOAEL | oral: feed | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| 10 | mg/kg bw/day | NOAEL | oral | mouse | COSMOS_DB |
| 25 | mg/kg bw/day | NOAEL | oral | mouse | COSMOS_DB |
| 75 | mg/kg bw/day | NOAEL | oral | mouse | COSMOS_DB |
| 89.1 | mg/kg bw/day | NOAEL | oral | mouse | COSMOS_DB |
| 350 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
Showing 15 of 15 studies
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Skin Conditioning
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
PIPERINE
ChEMBL Phase
2
Adverse Events
2
Bioactivity
6
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
1 food-safety record found.
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Piperine?
Piperine appears on 5 regulatory/inventory lists including active_ingredient; Pesticides, IFRA Transparency, Europe, and 2 more. Source: EPA CPDat.
Is Piperine used in cosmetics?
Yes, Piperine is also indexed as a cosmetic ingredient under the name Piperine. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Piperine come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does Piperine have different safety status in cosmetics vs industrial chemicals?
Piperine is classified GHS Danger (H301) in the chemicals database but is allowed in EU cosmetics.
Is Piperine used outside industrial chemicals?
Piperine also appears in cosmetics, pharmaceutical, food safety, cannabis databases.