Chemical Family
Sorted by lowest NOAEL first
Preservatives NOAEL Comparison
This page compares public raw NOAEL endpoint rows for Phenoxyethanol, Methylisothiazolinone, Benzisothiazolinone, Chlorphenesin, Sodium Benzoate. Values are pulled from noael_studies_public with NOAEL endpoint, mg/kg-family unit, and non-threshold qualifier filters.
Substances
5
With NOAEL Rows
4
Unique Sources
6
Lowest Indexed NOAEL
0.018 mg/kg bw/d
Benzisothiazolinone
Compare Families
Source Agreement Highlights
Benzisothiazolinone
Wide disagreement
Highest indexed NOAEL is 228,611.1111x the lowest.
SCCS Opinion, ECHA, SCCNFP Opinion
Sodium Benzoate
Wide disagreement
Highest indexed NOAEL is 1,201.3889x the lowest.
WHO/JECFA, COSMOS DB, ECHA
Methylisothiazolinone
Wide disagreement
Highest indexed NOAEL is 4.98x the lowest.
CIR Safety Assessment, SCCNFP Opinion, ECHA
| Substance | CAS | Lowest NOAEL | Highest NOAEL | # Studies | EU Status | Sources |
|---|---|---|---|---|---|---|
| Benzisothiazolinone | 2634-33-5 | 0.018 mg/kg bw/d | 4,115 mg/kg bw | 29 | restricted; max Permitted in rinse-off cosmetics; restricted or banned in leave-on products | SCCS Opinion, ECHA, SCCNFP Opinion
Wide disagreement |
| Phenoxyethanol | 122-99-6 | 2 mg/kg | 1,000 mg/kg bw/day | 44 | restricted; max 1.0% | SCCS Opinion
Single source |
| Sodium Benzoate | 532-32-1 | 3.6 mg/kg bw/day | 4,325 mg/kg bw/day | 32 | restricted; max 0.5% as benzoic acid equivalent | WHO/JECFA, COSMOS DB, ECHA
Wide disagreement |
| Methylisothiazolinone | 2682-20-4 | 10 mg/kg/d | 49.8 mg/kg bw/d | 34 | restricted; max 0.0015% in rinse-off cosmetics only; banned in all leave-on cosmetics | CIR Safety Assessment, SCCNFP Opinion, ECHA
Wide disagreement |
| Chlorphenesin | 104-29-0 | - | - | 0 | restricted; max 0.3% | -
No NOAEL rows |