Chemical Family Sorted by lowest NOAEL first

Parabens NOAEL Comparison

This page compares public raw NOAEL endpoint rows for Methylparaben, Ethylparaben, Propylparaben, Butylparaben, Isopropylparaben, Isobutylparaben. Values are pulled from noael_studies_public with NOAEL endpoint, mg/kg-family unit, and non-threshold qualifier filters.

Substances
6
With NOAEL Rows
4
Unique Sources
5
Lowest Indexed NOAEL
0.105 mg/kg bw/day
Methylparaben

Source Agreement Highlights

Methylparaben Wide disagreement
Highest indexed NOAEL is 11,238.0952x the lowest.
SCCS Opinion, CIR Safety Assessment, COSMOS DB, ECHA
Propylparaben Wide disagreement
Highest indexed NOAEL is 2,850x the lowest.
SCCS Opinion, ECHA, COSMOS DB
Substance CAS Lowest NOAEL Highest NOAEL # Studies EU Status Sources
Methylparaben 99-76-3 0.105 mg/kg bw/day 1,180 mg/kg bw/day 58 restricted; max 0.4% (as acid); mixture cap all parabens 0.8%
SCCS Opinion, CIR Safety Assessment, COSMOS DB +1 more
Wide disagreement
Propylparaben 94-13-3 2 mg/kg/day 5,700 mg/kg bw/day 76 restricted; max 0.14% (as acid)
SCCS Opinion, ECHA, COSMOS DB
Wide disagreement
Butylparaben 94-26-8 2 mg/kg bw/day 1,504 mg/kg bw/day 120 restricted; max 0.14% (as acid)
SCCS Opinion
Single source
Ethylparaben 120-47-8 1,030 mg/kg bw/day 1,030 mg/kg bw/day 2 restricted; max 0.4% single ester; 0.8% mixture of esters (sum of methyl+ethyl+propyl+butylparaben)
EFSA
Single source
Isopropylparaben 4191-73-5 - - 0 prohibited -
No NOAEL rows
Isobutylparaben 4247-02-3 - - 0 prohibited -
No NOAEL rows

Ingredient Records