Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
4 study endpoints found for 1,2,6-Hexanetriol. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 0.5 other | oral | rat | oral | REACH |
| NOAEL | 25 other | dermal | rat | dermal | REACH |
| NOAEL | 2.2 mg/kg bw/day | dermal | code:3484 | dermal | REACH |
| NOAEL | 289 mg/kg bw/day | oral | dog | oral | REACH |
Expert Verdict
GHS: 88.9% of notifications report no hazard criteria met; minor H315 (skin irritation) and H319 (eye irritation) flags in 11.1% of reports
Frequently Asked Questions
Is 1,2,6-Hexanetriol safe in cosmetics?
GHS: 88.9% of notifications report no hazard criteria met; minor H315 (skin irritation) and H319 (eye irritation) flags in 11.1% of reports The EU classifies 1,2,6-Hexanetriol as "permitted". Safety rating: GOOD. 4 toxicological study endpoint(s) are available in our database.
Is 1,2,6-Hexanetriol allowed in the EU?
1,2,6-Hexanetriol EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does 1,2,6-Hexanetriol do in cosmetics?
1,2,6-Hexanetriol functions as: Humectant, solvent, viscosity controlling. It is classified as a cosmetic ingredient in our database. CAS number: 106-69-4.
What is the Margin of Safety for 1,2,6-Hexanetriol?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for 1,2,6-Hexanetriol?
The NOAEL (No Observed Adverse Effect Level) for 1,2,6-Hexanetriol is 0.5 other based on a oral study via oral route in rat. A total of 4 study endpoints are available. Source: REACH.
Compliance Tools
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Related Ingredients
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