Is 1,2,6-Hexanetriol safe in cosmetics?
1,2,6-Hexanetriol has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
1,2,6-Hexanetriol
Also known as: (±)-1,2,6-Hexanetriol, 1,2,6-Trihydroxyhexane, 4-01-00-02784, BRN 1304479, EINECS 203-424-6 (+3 more)
INCI: 1,2,6-HEXANETRIOL
1,2,6-Hexanetriol (CAS 106-69-4) is a cosmetic cosmetic ingredient functioning as Humectant, solvent, viscosity controlling. NOAEL 289 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 106-69-4 →
Auto-generated CPSR Part A draft with source citations
Function
Humectant, solvent, viscosity controlling
Safety Rating
GOOD
Chemistry & Identifiers
EC Number
203-424-6
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
No FDA restriction; not specifically CIR-reviewed as standalone
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for 1,2,6-Hexanetriol.
Calculate MoS for your specific formulation with the MoS Calculator.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for 1,2,6-Hexanetriol across SCCS product categories, with measured dermal absorption where available.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Humectant
Solvent
Viscosity modifier
Expert Verdict
Expert safety assessment and concern-level summary for 1,2,6-Hexanetriol.
Known Synonyms
(±)-1,2,6-Hexanetriol
1,2,6-Trihydroxyhexane
4-01-00-02784
BRN 1304479
EINECS 203-424-6
Hexanetriol-1,2,6
NSC 404957
UNII-W45XXM0XWE
Chemical Function
Solvent
Humectant
Viscosity modifier
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3184716
Frequently Asked Questions
Is 1,2,6-Hexanetriol allowed in the EU?
1,2,6-Hexanetriol EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does 1,2,6-Hexanetriol do in cosmetics?
1,2,6-Hexanetriol functions as: Humectant, solvent, viscosity controlling. It is classified as a cosmetic ingredient in our database. CAS number: 106-69-4.
Is 1,2,6-Hexanetriol used outside cosmetics?
1,2,6-Hexanetriol also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check 1,2,6-Hexanetriol compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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