Is Butadiene safe in cosmetics?
Butadiene has a safety rating of "POOR" in our database. EU status: prohibited. US status: prohibited.
Butadiene
Also known as: 1,3 Butadieno, Buta-1,3-dien, Butadiene-1,3, Vinylethylene, Erythrene (+10 more)
INCI: BUTADIENE
Butadiene (CAS 106-99-0) is a cosmetic cosmetic ingredient functioning as Industrial monomer; not intended for direct cosmetic use. EU Regulation 1223/2009 status: prohibited; GHS signal word DANGER. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 106-99-0 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Butadiene is prohibited in EU cosmetics but has active industrial GHS classifications (H220, H280, H340, H350, H361, H412, H361fd, H335).
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Industrial monomer; not intended for direct cosmetic use
Safety Rating
POOR
Chemistry & Identifiers
IUPAC Name
buta-1,3-diene
InChIKey
KAKZBPTYRLMSJV-UHFFFAOYSA-N
Regulatory Status
EU EU Status
prohibited
US US Status
prohibited
US Notes
Prohibited substance; not applicable for cosmetic use
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Butadiene.
Calculate MoS for your specific formulation with the MoS Calculator.
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Signal Word
DANGER
Pictograms
CylinderGasFlamFlameCancerHealth haz
Hazard Statements
Contains gas under pressure; may explode if heated Extremely flammable gas May cause cancer May cause genetic defects
Short-term Exposure Effects
The substance at very high concentrations is irritating to the eyes and respiratory tract. Rapid evaporation of the liquid may cause frostbite. Inhalation of high concentrations may cause depression of the central nervous system.
Long-term Exposure Effects
The substance may have effects on the bone marrow. This substance is carcinogenic to humans. May cause heritable genetic damage to human germ cells.
Routes of Exposure
The substance can be absorbed into the body by inhalation.
IARC Carcinogenicity
International Agency for Research on Cancer (WHO) monograph evaluation.
IARC Group
1
Volume
Sup 7, 54, 71, 97, 100F
Evaluation Year
2009
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Danger
Pictograms
FlammableCompressed GasHealth Hazard
Hazard Class and Category
Flam. Gas 1; Press. Gas; Carc. 1A; Muta. 1B
Hazard Statements
- H220 Extremely flammable gas
- H350 May cause cancer
- H340 May cause genetic defects
Inserted via ATP: CLP00
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000,000 - 10,000,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
EU CosIng Annex Listing
European Commission CosIng database Annex references per Regulation (EC) No 1223/2009.
Annex II — Prohibited
Ref: 463
(EC) 2009/1223
CMR: Carcinogenic Cat. 1A(),Mutagenic Cat. 1B()
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (II - Prohibited)
BRIN Brazil/India Cosmetics
Brazil: Prohibited
India: Prohibited (GNRAS)
Additional Jurisdictional Restrictions (4)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| IN | banned | - | all cosmetics |
| CA | banned | - | - |
| ASEAN | banned | - | All cosmetic products prohibited |
| KR | prohibited | - | - |
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (7)
Carcinogen Classification
1, carcinogenic to humans. (L135)
Source: Toxin and Toxin Target Database (T3DB)
Carcinogen Classification
1,3-Butadiene | Group 1: Carcinogenic to humans | Volume Sup 7: Overall Evaluations of Carcinogenicity: An Updating of IARC Monographs Volumes 1 to 42, 1987; 440 pages; ISBN 92-832-1411-0 (out of print) | Volume 54: (1992) Occupational Exposures to Mists and Vapours from Strong Inorganic Acids; and Other Industrial Chemicals | Volume 71: (1999) Re-evaluation of Some Organic Chemicals, Hydrazine an
Source: International Agency for Research on Cancer (IARC)
Carcinogen Classification
1,3-Butadiene | TR-434: Toxicology and Carcinogenesis Studies of 1,3-Butadiene (CASRN 106-99-0) in B6C3F1 Mice (Inhalation Studies) (1993 ) | 11/21/91 | Chemical Not Tested in Species/Sex | Chemical Not Tested in Species/Sex | Clear Evidence | Clear Evidence | The previous inhalation studies of 1,3-butadiene (TR-288) in male and female B6C3F1 mice provided clear evidence of carcinogenicit
Source: NTP Technical Reports
Carcinogen Classification
1,3-Butadiene | TR-288: Toxicology and Carcinogenesis Studies of 1,3-Butadiene (CASRN 106-99-0) in B6C3F1 Mice (Inhalation Studies) (1984 ) | 10/28/83 | Chemical Not Tested in Species/Sex | Chemical Not Tested in Species/Sex | Clear Evidence | Clear Evidence | Under the conditions of these studies, there was clear evidence of carcinogenicity for 1,3-butadiene in male and female B6C3F1 mic
Source: NTP Technical Reports
Evidence for Carcinogenicity
Evaluation - 1,3-Butadiene There is sufficient evidence in humans for the carcinogenicity of 1,3-butadiene. 1,3-Butadiene causes cancer of the hematolymphatic organs. There is sufficient evidence in experimental animals for the carcinogenicity of 1,3-butadiene. In mice, 1,3-butadiene causes tumors of the hematopoietic system (lymphoma and histiocytic sarcoma), heart (hemangiosarcoma), lung, forest
Source: Hazardous Substances Data Bank (HSDB)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Monomers
No specific technical function
Regulatory List Membership (4)
California Proposition 65 (OEHHA)
EU Banned in Cosmetics
FDA Indirect Food Contact Additives
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for Butadiene.
Regulatory Flags
prop65
eu_banned_cosmetics
eu_cosing_listed
Known Synonyms
1,3 Butadieno
Buta-1,3-dien
Butadiene-1,3
Vinylethylene
Erythrene
Butadiene monomer
Butadiene-1,3-uninhibited
EINECS 203-450-8
NCI-C50602
Buta-1,3-dieen
Butadieen
Butadien
UNII-JSD5FGP5VD
CH2=CH-CH=CH2
alpha,gamma-butadiene
Chemical Function
Monomers
No specific technical function
Regulatory Lists
CEDI
OEHHA Proposition 65 (3/2019)
detected; drinking_water; MN Chemical Screening
detected; drinking_water; MN Chemical Screening
children
Europe; Food contact items; Toys and children's products
Europe; Food contact items; Toys and children's products
OEHHA Proposition 65 (1/2023)
banned; Europe; Personal care
Cons electronics mech appliances and machinery; Europe
drinking_water; Europe; manufacturing; plastic_additive
Indirect additives food contact (10/2018)
Europe; Road vehicles
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
BUTADIENE
ChEMBL ID
CHEMBL537970
Frequently Asked Questions
Is Butadiene allowed in the EU?
Butadiene EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Butadiene do in cosmetics?
Butadiene functions as: Industrial monomer; not intended for direct cosmetic use. It is classified as a cosmetic ingredient in our database. CAS number: 106-99-0.
Is Butadiene classified as hazardous under GHS?
Butadiene carries a GHS signal word of "DANGER". Hazard statements: Contains gas under pressure; may explode if heated Extremely flammable gas May cause cancer May cause genetic defects. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.
Is Butadiene used outside cosmetics?
Butadiene also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Butadiene have different safety status in cosmetics vs industrial chemicals?
Butadiene is prohibited in EU cosmetics but has active industrial GHS classifications (H220, H280, H340, H350, H361, H412, H361fd, H335).
Compliance Tools
Check Butadiene compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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