Poor Cosmetic Ingredient GHS Classified

Butadiene

INCI: BUTADIENE

CAS Number

106-99-0

Function

Industrial monomer; not intended for direct cosmetic use

Safety Rating

POOR

Regulatory Status

🇪🇺 EU Status prohibited

🇺🇸 US Status prohibited

US Notes Prohibited substance; not applicable for cosmetic use

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)

not established

Dermal Absorption

high

Sensitization

low

Calculate MoS for your specific formulation with the MoS Calculator.

GHS Hazard Classification

Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.

Signal Word

DANGER

Pictograms

cylinder;gas; flam;flame; cancer;health haz

Hazard Statements

Contains gas under pressure; may explode if heated Extremely flammable gas May cause cancer May cause genetic defects

Short-term Exposure Effects

The substance at very high concentrations is irritating to the eyes and respiratory tract. Rapid evaporation of the liquid may cause frostbite. Inhalation of high concentrations may cause depression of the central nervous system.

Long-term Exposure Effects

The substance may have effects on the bone marrow. This substance is carcinogenic to humans. May cause heritable genetic damage to human germ cells.

Routes of Exposure

The substance can be absorbed into the body by inhalation.

Expert Verdict

PROHIBITED. IARC Group 1 carcinogen listed in EU Annex II. Cannot be intentionally added to any cosmetic product. If detected as a residual monomer in polymers, must be below detectable limits or technically unavoidable trace levels.

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Concern Level: High

Regulatory Flags

prop65 eu_banned_cosmetics eu_cosing_listed

Frequently Asked Questions

Is Butadiene safe in cosmetics?

Is Butadiene allowed in the EU?

Butadiene EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.

What does Butadiene do in cosmetics?

Butadiene functions as: Industrial monomer; not intended for direct cosmetic use. It is classified as a cosmetic ingredient in our database. CAS number: 106-99-0.

What is the Margin of Safety for Butadiene?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

Is Butadiene classified as hazardous under GHS?

Butadiene carries a GHS signal word of "DANGER". Hazard statements: Contains gas under pressure; may explode if heated Extremely flammable gas May cause cancer May cause genetic defects. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.

Compliance Tools

Check Butadiene compliance across multiple jurisdictions:

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Ingredient Decoder

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82 Allergen Checker

Check for EU declarable fragrance allergens

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Substance Compliance

Check compliance across 55 jurisdictions

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MoS Calculator

Calculate Margin of Safety using SCCS methodology

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Heavy Metal Limits

Compare limits across jurisdictions

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