Is 2-Dodecenal safe in cosmetics?
2-Dodecenal has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
MODERATE
Cosmetic Ingredient
2-Dodecenal
Also known as: Dodec-2-en-1-al, dodec-2-ene-1-al, dodec-2-enal, DODECEN-(2)-OL-(1), EINECS 225-402-5 (+4 more)
INCI: 2-DODECENAL
2-Dodecenal (CAS 4826-62-4) is a cosmetic cosmetic ingredient functioning as Fragrance. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and food safety data.
Function
Fragrance
Editorial assessment
MODERATE
Preliminary editorial note — not a computed safety verdict.
Chemistry & Identifiers
IUPAC Name
(E)-dodec-2-enal
InChIKey
SSNZFFBDIMUILS-ZHACJKMWSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — no FDA restriction
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for 2-Dodecenal.
Calculate MoS for your specific formulation with the MoS Calculator.
HRIPT Human Patch Test Studies
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 675 | - | - |
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (2)
JECFA Number
1350
Source: WHO/JECFA
JECFA Evaluation
2-DODECENAL | 2004 | No safety concern at current levels of intake when used as a flavouring agent | TRS 928-JECFA 63/77 | FAS 54-JECFA 63/317
Source: WHO/JECFA
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (3)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Editorial summary
Preliminary editorial summary for 2-Dodecenal — not a computed safety verdict. See the sourced toxicological data above.
Regulatory Flags
fragrance-component
ifra_fragrance
fda_food_additive
jecfa_safe
Known Synonyms
Dodec-2-en-1-al
dodec-2-ene-1-al
dodec-2-enal
DODECEN-(2)-OL-(1)
EINECS 225-402-5
FEMA No. 2402
3-Nonylacrolein
NSC 22287
beta-Octyl acrolein
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
IFRA Transparency
Europe
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
consumer_product
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in food safety data.
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
2-DODECENAL
ADI
No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
Food Category
flavoring
Frequently Asked Questions
Is 2-Dodecenal allowed in the EU?
2-Dodecenal EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does 2-Dodecenal do in cosmetics?
2-Dodecenal functions as: Fragrance. It is classified as a cosmetic ingredient in our database. CAS number: 4826-62-4.
Is 2-Dodecenal used outside cosmetics?
2-Dodecenal also appears in industrial chemical safety and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check 2-Dodecenal compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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