Is 2-Ethyl-3,5-Dimethylpyrazine safe in cosmetics?
2-Ethyl-3,5-Dimethylpyrazine has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
2-Ethyl-3,5-Dimethylpyrazine
Also known as: Pyrazine, 2-ethyl-3,5-dimethyl-, 2,6-Dimethyl-3-ethylpyrazine, 3,5-Dimethyl-2-ethylpyrazine, 3-Ethyl-2,6-dimethylpyrazine, EC No.: 237-694-1 (+4 more)
INCI: 2-ETHYL-3,5-DIMETHYLPYRAZINE
2-Ethyl-3,5-Dimethylpyrazine (CAS 13925-07-0) is a cosmetic cosmetic ingredient functioning as Perfuming. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 13925-07-0 →
Auto-generated CPSR Part A draft with source citations
Function
Perfuming
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
2-ethyl-3,5-dimethylpyrazine
InChIKey
JZBCTZLGKSYRSF-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Not individually restricted; FEMA GRAS as flavoring
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for 2-Ethyl-3,5-Dimethylpyrazine.
Calculate MoS for your specific formulation with the MoS Calculator.
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (4)
JECFA Number
775
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Number
776
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
2,6-DIMETHYL-3-ETHYLPYRAZINE | 2001 | No safety concern at current levels of intake when used as a flavouring agent | TRS 909-JECFA 57/51 | FAS 48-JECFA 57/135
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
3-ETHYL-2,6-DIMETHYLPYRAZINE | 2001 | No safety concern at current levels of intake when used as a flavouring agent | TRS 909-JECFA 57/51 | FAS 48-JECFA 57/135
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (2)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for 2-Ethyl-3,5-Dimethylpyrazine.
Regulatory Flags
fragrance-component
ifra_fragrance
fda_food_additive
Known Synonyms
Pyrazine, 2-ethyl-3,5-dimethyl-
2,6-Dimethyl-3-ethylpyrazine
3,5-Dimethyl-2-ethylpyrazine
3-Ethyl-2,6-dimethylpyrazine
EC No.: 237-694-1
5-23-05-00440
BRN 0636984
EINECS 237-694-1
UNII-R182EY5L8C
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
Europe
IFRA Transparency
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL328856
Frequently Asked Questions
Is 2-Ethyl-3,5-Dimethylpyrazine allowed in the EU?
2-Ethyl-3,5-Dimethylpyrazine EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does 2-Ethyl-3,5-Dimethylpyrazine do in cosmetics?
2-Ethyl-3,5-Dimethylpyrazine functions as: Perfuming. It is classified as a cosmetic ingredient in our database. CAS number: 13925-07-0.
Is 2-Ethyl-3,5-Dimethylpyrazine used outside cosmetics?
2-Ethyl-3,5-Dimethylpyrazine also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
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Ingredient Decoder
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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