Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
1 study endpoint found for 2-Ethyl-3,5-Dimethylpyrazine. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 11.1 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
Expert Verdict
Not genotoxic based on read-across within pyrazine group; limited individual data available.
Regulatory Flags
Frequently Asked Questions
Is 2-Ethyl-3,5-Dimethylpyrazine safe in cosmetics?
Not genotoxic based on read-across within pyrazine group; limited individual data available. The EU classifies 2-Ethyl-3,5-Dimethylpyrazine as "permitted". Safety rating: GOOD. 1 toxicological study endpoint(s) are available in our database.
Is 2-Ethyl-3,5-Dimethylpyrazine allowed in the EU?
2-Ethyl-3,5-Dimethylpyrazine EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does 2-Ethyl-3,5-Dimethylpyrazine do in cosmetics?
2-Ethyl-3,5-Dimethylpyrazine functions as: Perfuming. It is classified as a cosmetic ingredient in our database. CAS number: 13925-07-0.
What is the Margin of Safety for 2-Ethyl-3,5-Dimethylpyrazine?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for 2-Ethyl-3,5-Dimethylpyrazine?
The NOAEL (No Observed Adverse Effect Level) for 2-Ethyl-3,5-Dimethylpyrazine is 11.1 mg/kg bw/day based on a Subchronic study via oral route in rat. Source: COSMOS_DB.
Compliance Tools
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Related Ingredients
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