2-Hydroxyethyl Acrylate
INCI: HYDROXYETHYL ACRYLATE
Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
6 study endpoints found for 2-Hydroxyethyl Acrylate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 125 mg/kg bw/day | oral | dog | oral | REACH |
| NOAEL | >=196 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 40 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 150 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 100 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 100 mg/kg bw/day | oral | - | oral | REACH |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Expert Verdict
Residual monomers cause allergic contact dermatitis and respiratory issues in nail technicians; strict adherence to curing time is essential
Frequently Asked Questions
Is 2-Hydroxyethyl Acrylate safe in cosmetics?
Residual monomers cause allergic contact dermatitis and respiratory issues in nail technicians; strict adherence to curing time is essential The EU classifies 2-Hydroxyethyl Acrylate as "permitted". Safety rating: MODERATE. 6 toxicological study endpoint(s) are available in our database.
Is 2-Hydroxyethyl Acrylate allowed in the EU?
2-Hydroxyethyl Acrylate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does 2-Hydroxyethyl Acrylate do in cosmetics?
2-Hydroxyethyl Acrylate functions as: Film forming, primarily used in nail enhancement products (UV/LED gel systems). It is classified as a cosmetic ingredient in our database. CAS number: 818-61-1.
What is the Margin of Safety for 2-Hydroxyethyl Acrylate?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for 2-Hydroxyethyl Acrylate?
The NOAEL (No Observed Adverse Effect Level) for 2-Hydroxyethyl Acrylate is 125 mg/kg bw/day based on a oral study via oral route in dog. A total of 6 study endpoints are available. Source: REACH.
Is 2-Hydroxyethyl Acrylate classified as hazardous under GHS?
2-Hydroxyethyl Acrylate carries a GHS signal word of "DANGER". Hazard statements: Fatal in contact with skin or if inhaled Harmful if swallowed Causes skin irritation Causes serious eye irritation May cause allergic skin reaction May be harmful if swallowed and enters airways Very toxic to aquatic life. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.
Compliance Tools
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Related Ingredients
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