Good Cosmetic Ingredient NOAEL Data

2-Heptylcyclopentanone

INCI: 2-HEPTYLCYCLOPENTANONE

CAS Number
137-03-1
Function
Fragrance ingredient (cyclopentanone class)
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Not specifically restricted by FDA; RIFM-reviewed

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
moderate
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

1 study endpoint found for 2-Heptylcyclopentanone. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL >=800 mg/kg bw/day oral rat oral REACH

Expert Verdict

RIFM review covers acute toxicity, skin irritation, mucous membrane irritation, skin sensitization, phototoxicity, photoallergy, and genotoxicity endpoints. No major safety flags identified at typical fragrance use levels.

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Concern Level: Low

Regulatory Flags

potential-allergen fragrance-component epa_safer_alternative ifra_fragrance

Frequently Asked Questions

Is 2-Heptylcyclopentanone safe in cosmetics?

RIFM review covers acute toxicity, skin irritation, mucous membrane irritation, skin sensitization, phototoxicity, photoallergy, and genotoxicity endpoints. No major safety flags identified at typical fragrance use levels. The EU classifies 2-Heptylcyclopentanone as "permitted". Safety rating: GOOD. 1 toxicological study endpoint(s) are available in our database.

Is 2-Heptylcyclopentanone allowed in the EU?

2-Heptylcyclopentanone EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does 2-Heptylcyclopentanone do in cosmetics?

2-Heptylcyclopentanone functions as: Fragrance ingredient (cyclopentanone class). It is classified as a cosmetic ingredient in our database. CAS number: 137-03-1.

What is the Margin of Safety for 2-Heptylcyclopentanone?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for 2-Heptylcyclopentanone?

The NOAEL (No Observed Adverse Effect Level) for 2-Heptylcyclopentanone is >=800 mg/kg bw/day based on a oral study via oral route in rat. Source: REACH.

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