Is 2-Heptylcyclopentanone safe in cosmetics?
2-Heptylcyclopentanone has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
2-Heptylcyclopentanone
Also known as: Cyclopentanone, 2-heptyl-, Alismone, 4-07-00-00104, BRN 2043445, Cyclopentanone, 2-n-heptyl- (+8 more)
INCI: 2-HEPTYLCYCLOPENTANONE
2-Heptylcyclopentanone (CAS 137-03-1) is a cosmetic cosmetic ingredient functioning as Fragrance ingredient (cyclopentanone class). NOAEL 800 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 137-03-1 →
Auto-generated CPSR Part A draft with source citations
Function
Fragrance ingredient (cyclopentanone class)
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
2-heptylcyclopentan-1-one
InChIKey
PJXHBTZLHITWFX-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Not specifically restricted by FDA; RIFM-reviewed
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for 2-Heptylcyclopentanone.
Calculate MoS for your specific formulation with the MoS Calculator.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for 2-Heptylcyclopentanone across SCCS product categories, with measured dermal absorption where available.
Sensitization AOP Dashboard
Adverse Outcome Pathway data across 5 assays (DPRA, KeratinoSens, hCLAT, LLNA, NESIL) aggregated from public sources.
NESIL
775 µg/cm²
GHS: 1B
Human: positive
Source: HPPT: [59] Kligman AM (1973): Report to RIFM, 9 May, unpublished.
HRIPT Human Patch Test Studies
2 human repeat insult patch tests aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 6480 | - | - |
| HRIPT | - | 0 | 775 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Endocrine Disruptors
Potential endocrine disrupting compound
Source: NORMAN Suspect List Exchange
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Deodorizer
Fragrance
Regulatory List Membership (3)
IFRA Fragrance Transparency List
EPA Safer Chemical Ingredients List (SCIL)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for 2-Heptylcyclopentanone.
Regulatory Flags
potential-allergen
fragrance-component
epa_safer_alternative
ifra_fragrance
Known Synonyms
Cyclopentanone, 2-heptyl-
Alismone
4-07-00-00104
BRN 2043445
Cyclopentanone, 2-n-heptyl-
EINECS 205-273-1
alpha-Heptyl cyclopentanone
2-n-Heptyl cyclopentanone
alpha-Heptylcyclopentanone
2-n-Heptylcyclopentanone
2-Heptylcyclopentan-1-one
NSC 78468
UNII-4984B2X8AH
Chemical Function
Deodorizer
Fragrance
Regulatory Lists
SCIL (9/2019)
IFRA Transparency
consumer_product
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3185887
Frequently Asked Questions
Is 2-Heptylcyclopentanone allowed in the EU?
2-Heptylcyclopentanone EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does 2-Heptylcyclopentanone do in cosmetics?
2-Heptylcyclopentanone functions as: Fragrance ingredient (cyclopentanone class). It is classified as a cosmetic ingredient in our database. CAS number: 137-03-1.
Is 2-Heptylcyclopentanone used outside cosmetics?
2-Heptylcyclopentanone also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check 2-Heptylcyclopentanone compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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