Is 2-Isobutylquinoline safe in cosmetics?
2-Isobutylquinoline has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted. 1 toxicological study endpoint(s) are available in our database.
2-Isobutylquinoline
Also known as: 2-Isobutoxyethanol, Isobutyl cellosolve, Ethanol, 2-(2-methylpropoxy)-, BRN 1732707, EINECS 224-658-5 (+1 more)
INCI: 2-ISOBUTYLQUINOLINE
2-Isobutylquinoline (CAS 4439-24-1) is a cosmetic cosmetic ingredient functioning as Fragrance ingredient. Reported NOAEL =150 mg/kg bw/day in Rat (ToxValDB_ECHA_IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 4439-24-1 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
2-Isobutylquinoline is classified GHS Danger (H226, H302, H311, H314, H318, H373, H319, H331) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Fragrance ingredient
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
2-(2-methylpropoxy)ethanol
InChIKey
HHAPGMVKBLELOE-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted; RIFM safety assessment completed
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for 2-Isobutylquinoline.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
1 study endpoint found for 2-Isobutylquinoline. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =150 mg/kg bw/day | oral | Rat | subchronic | ToxValDB_ECHA_IUCLID |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1 - 10 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Expert Verdict
Expert safety assessment and concern-level summary for 2-Isobutylquinoline.
Regulatory Flags
potential-allergen
fragrance-component
ifra_fragrance
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to 2-Isobutylquinoline by CAS number or substance name.
Studies
1
Lowest NOAEL
150 mg/kg bw/day
Highest NOAEL
150 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Known Synonyms
2-Isobutoxyethanol
Isobutyl cellosolve
Ethanol, 2-(2-methylpropoxy)-
BRN 1732707
EINECS 224-658-5
Ektasolve EIB
Frequently Asked Questions
Is 2-Isobutylquinoline allowed in the EU?
2-Isobutylquinoline EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does 2-Isobutylquinoline do in cosmetics?
2-Isobutylquinoline functions as: Fragrance ingredient. It is classified as a cosmetic ingredient in our database. CAS number: 4439-24-1.
What is the NOAEL for 2-Isobutylquinoline?
The NOAEL (No Observed Adverse Effect Level) for 2-Isobutylquinoline is =150 mg/kg bw/day based on a subchronic study via oral route in Rat. Source: ToxValDB_ECHA_IUCLID.
Is 2-Isobutylquinoline used outside cosmetics?
2-Isobutylquinoline also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does 2-Isobutylquinoline have different safety status in cosmetics vs industrial chemicals?
2-Isobutylquinoline is classified GHS Danger (H226, H302, H311, H314, H318, H373, H319, H331) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check 2-Isobutylquinoline compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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