2-Isobutyl-3-methoxypyrazine

INCI: 2-ISOBUTYL-3-METHOXYPYRAZINE

CAS Number
24683-00-9 [^1_23][^1_24]
Function
Fragrance ingredient with green pepper and earthy character
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted in cosmetics

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Not genotoxic or photoirritating; used at extremely low concentrations due to high potency (detection threshold in ppb range) with no reproductive or repeated dose concerns at typical use levels.

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Concern Level: Low

Regulatory Flags

fragrance-component ifra_fragrance fda_food_additive jecfa_safe

Frequently Asked Questions

Is 2-Isobutyl-3-methoxypyrazine safe in cosmetics?

Not genotoxic or photoirritating; used at extremely low concentrations due to high potency (detection threshold in ppb range) with no reproductive or repeated dose concerns at typical use levels. The EU classifies 2-Isobutyl-3-methoxypyrazine as "permitted". Safety rating: GOOD.

Is 2-Isobutyl-3-methoxypyrazine allowed in the EU?

2-Isobutyl-3-methoxypyrazine EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does 2-Isobutyl-3-methoxypyrazine do in cosmetics?

2-Isobutyl-3-methoxypyrazine functions as: Fragrance ingredient with green pepper and earthy character. It is classified as a cosmetic ingredient in our database. CAS number: 24683-00-9 [^1_23][^1_24].

What is the Margin of Safety for 2-Isobutyl-3-methoxypyrazine?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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