Is 2-Oleamido-1,3-Octadecanediol safe in cosmetics?
2-Oleamido-1,3-Octadecanediol has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
2-Oleamido-1,3-Octadecanediol
Also known as: 9-Octadecenamide, N-(2-hydroxy-1-(hydroxymethyl)heptadecyl)-, (9Z)-, (Z)-N-(1,3-Dihydroxyoctadecan-2-yl)octadec-9-enamide, (9Z)-N-(2-Hydroxy-1-(hydroxymethyl)heptadecyl)-9-octadecenamide, UNII-30D478BUNR
INCI: 2-OLEAMIDO-1,3-OCTADECANEDIOL
2-Oleamido-1,3-Octadecanediol (CAS 54422-45-6) is a cosmetic cosmetic ingredient functioning as Skin conditioning (ceramide analogue/pseudoceramide). EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 54422-45-6 →
Auto-generated CPSR Part A draft with source citations
Function
Skin conditioning (ceramide analogue/pseudoceramide)
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
(Z)-N-(1,3-dihydroxyoctadecan-2-yl)octadec-9-enamide
InChIKey
MJQIARGPQMNBGT-ZCXUNETKSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
No FDA restriction; widely used in skincare products
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for 2-Oleamido-1,3-Octadecanediol.
Calculate MoS for your specific formulation with the MoS Calculator.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for 2-Oleamido-1,3-Octadecanediol.
Known Synonyms
9-Octadecenamide, N-(2-hydroxy-1-(hydroxymethyl)heptadecyl)-, (9Z)-
(Z)-N-(1,3-Dihydroxyoctadecan-2-yl)octadec-9-enamide
(9Z)-N-(2-Hydroxy-1-(hydroxymethyl)heptadecyl)-9-octadecenamide
UNII-30D478BUNR
Chemical Function
Softener and conditioner
Australian Status
AICIS status: listed_with_terms
Specific information requirements: Obligations to provide information apply. These obligations are: 1. A person introducing this chemical must tell us in writing within 28 calendar days if any of the following circumstances have occurred in relation to their introduction (importation or manufacture): a. the introduction volume of the chemical exceeds 1...
Frequently Asked Questions
Is 2-Oleamido-1,3-Octadecanediol allowed in the EU?
2-Oleamido-1,3-Octadecanediol EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does 2-Oleamido-1,3-Octadecanediol do in cosmetics?
2-Oleamido-1,3-Octadecanediol functions as: Skin conditioning (ceramide analogue/pseudoceramide). It is classified as a cosmetic ingredient in our database. CAS number: 54422-45-6.
Is 2-Oleamido-1,3-Octadecanediol used outside cosmetics?
2-Oleamido-1,3-Octadecanediol also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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