2,2'-Methylenebis 4-Aminophenol

INCI: 2,2'-METHYLENEBIS 4-AMINOPHENOL

CAS Number
63969-46-0 (free base)
Function
Hair dyeing - oxidation hair colorant (permanent hair dyes)
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status restricted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Coal tar hair dye exemption applies; subject to FDA labeling requirements (caution statement + patch test)

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
low
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Hair dye sensitization risk; must comply with Annex III maximum concentration and labeling; not for use outside hair dyeing applications

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Concern Level: Moderate

Regulatory Flags

potential-allergen colorant

Frequently Asked Questions

Is 2,2'-Methylenebis 4-Aminophenol safe in cosmetics?

Hair dye sensitization risk; must comply with Annex III maximum concentration and labeling; not for use outside hair dyeing applications The EU classifies 2,2'-Methylenebis 4-Aminophenol as "restricted". Safety rating: MODERATE.

Is 2,2'-Methylenebis 4-Aminophenol allowed in the EU?

2,2'-Methylenebis 4-Aminophenol EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.

What does 2,2'-Methylenebis 4-Aminophenol do in cosmetics?

2,2'-Methylenebis 4-Aminophenol functions as: Hair dyeing - oxidation hair colorant (permanent hair dyes). It is classified as a cosmetic ingredient in our database. CAS number: 63969-46-0 (free base).

What is the Margin of Safety for 2,2'-Methylenebis 4-Aminophenol?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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