2,2'-Methylenebis-4-Aminophenol HCl

INCI: 2,2'-METHYLENEBIS-4-AMINOPHENOL HCL (COLIPA Nยฐ A155)

CAS Number
27311-52-0 (dihydrochloride salt)
Function
Hair dyeing - oxidative and non-oxidative hair dye
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status restricted
EU Max Conc. 2.0%
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Coal tar hair dye exemption; labeling and patch test requirements apply

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
low
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Salt form of \#3 above; same sensitization and regulatory constraints apply; mandatory EU labeling for hair dye products; max 2.0% on head

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Concern Level: Moderate

Regulatory Flags

potential-allergen

Frequently Asked Questions

Is 2,2'-Methylenebis-4-Aminophenol HCl safe in cosmetics?

Salt form of \#3 above; same sensitization and regulatory constraints apply; mandatory EU labeling for hair dye products; max 2.0% on head The EU classifies 2,2'-Methylenebis-4-Aminophenol HCl as "restricted". Safety rating: MODERATE.

Is 2,2'-Methylenebis-4-Aminophenol HCl allowed in the EU?

2,2'-Methylenebis-4-Aminophenol HCl EU regulatory status: restricted. Maximum allowed concentration: 2.0%. This is based on EU Regulation 1223/2009 and its amendments.

What does 2,2'-Methylenebis-4-Aminophenol HCl do in cosmetics?

2,2'-Methylenebis-4-Aminophenol HCl functions as: Hair dyeing - oxidative and non-oxidative hair dye. It is classified as a cosmetic ingredient in our database. CAS number: 27311-52-0 (dihydrochloride salt).

What is the Margin of Safety for 2,2'-Methylenebis-4-Aminophenol HCl?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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