2,6-Dimethylpyrazine

INCI: 2,6-DIMETHYLPYRAZINE

CAS Number
108-50-9
Function
Fragrance (perfuming); also used as a flavoring agent with nutty/roasted character
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes FEMA GRAS as a flavoring substance; not individually regulated for cosmetic use beyond fragrance exemption

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Nitrogen-containing heterocycle - verify that your specific market accepts pyrazine derivatives in cosmetics without additional notification. Dual food/cosmetic use means food-grade purity specs may differ from cosmetic-grade

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Concern Level: Low

Regulatory Flags

fragrance-component ifra_fragrance fda_food_additive jecfa_safe

Frequently Asked Questions

Is 2,6-Dimethylpyrazine safe in cosmetics?

Nitrogen-containing heterocycle - verify that your specific market accepts pyrazine derivatives in cosmetics without additional notification. Dual food/cosmetic use means food-grade purity specs may differ from cosmetic-grade The EU classifies 2,6-Dimethylpyrazine as "permitted". Safety rating: GOOD.

Is 2,6-Dimethylpyrazine allowed in the EU?

2,6-Dimethylpyrazine EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does 2,6-Dimethylpyrazine do in cosmetics?

2,6-Dimethylpyrazine functions as: Fragrance (perfuming); also used as a flavoring agent with nutty/roasted character. It is classified as a cosmetic ingredient in our database. CAS number: 108-50-9.

What is the Margin of Safety for 2,6-Dimethylpyrazine?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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