Moderate Cosmetic Ingredient NOAEL Data

3-Amino-2,4-Dichlorophenol HCl

INCI: 3-AMINO-2,4-DICHLOROPHENOL HCL

CAS Number
61693-43-4
Function
Hair dyeing hydrochloride salt
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status prohibited
EU Max Conc. 1.5%
🇺🇸 US Status permitted
US Notes Coal tar hair dye exemption under FD&C Act §601(a)

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

2 study endpoints found for 3-Amino-2,4-Dichlorophenol HCl. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 80 mg/kg bw/day oral rat Subchronic COSMOS_DB
LOAEL 160 mg/kg bw/day oral rat Subchronic COSMOS_DB

Expert Verdict

Prohibited in EU as coal tar dye; permitted in US under exemption. Same warnings as free base apply: must not be used with nitrosating agents; maximum nitrosamine content 50 µg/kg; store in nitrite-free containers.

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Concern Level: Moderate

Frequently Asked Questions

Is 3-Amino-2,4-Dichlorophenol HCl safe in cosmetics?

Prohibited in EU as coal tar dye; permitted in US under exemption. Same warnings as free base apply: must not be used with nitrosating agents; maximum nitrosamine content 50 µg/kg; store in nitrite-free containers. The EU classifies 3-Amino-2,4-Dichlorophenol HCl as "prohibited". Safety rating: MODERATE. 2 toxicological study endpoint(s) are available in our database.

Is 3-Amino-2,4-Dichlorophenol HCl allowed in the EU?

3-Amino-2,4-Dichlorophenol HCl EU regulatory status: prohibited. Maximum allowed concentration: 1.5%. This is based on EU Regulation 1223/2009 and its amendments.

What does 3-Amino-2,4-Dichlorophenol HCl do in cosmetics?

3-Amino-2,4-Dichlorophenol HCl functions as: Hair dyeing hydrochloride salt. It is classified as a cosmetic ingredient in our database. CAS number: 61693-43-4.

What is the Margin of Safety for 3-Amino-2,4-Dichlorophenol HCl?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for 3-Amino-2,4-Dichlorophenol HCl?

The NOAEL (No Observed Adverse Effect Level) for 3-Amino-2,4-Dichlorophenol HCl is 80 mg/kg bw/day based on a Subchronic study via oral route in rat. A total of 2 study endpoints are available. Source: COSMOS_DB.

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