Good Cosmetic Ingredient NOAEL Data

3-Methyl-5-phenyl-2-pentenenitrile

INCI: 3-METHYL-5-PHENYL-2-PENTENENITRILE

CAS Number
93893-89-1
Function
Perfuming (fragrance ingredient)
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Not restricted; RIFM safety assessment published (2022)

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

1 study endpoint found for 3-Methyl-5-phenyl-2-pentenenitrile. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 50 mg/kg bw/day oral rat oral REACH

Expert Verdict

Nitrile functional group evaluated - not genotoxic in multiple GLP Ames studies (OECD TG 471); developmental/reproductive toxicity margins adequate

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Concern Level: Moderate

Regulatory Flags

fragrance-component ifra_fragrance

Frequently Asked Questions

Is 3-Methyl-5-phenyl-2-pentenenitrile safe in cosmetics?

Nitrile functional group evaluated - not genotoxic in multiple GLP Ames studies (OECD TG 471); developmental/reproductive toxicity margins adequate The EU classifies 3-Methyl-5-phenyl-2-pentenenitrile as "permitted". Safety rating: GOOD. 1 toxicological study endpoint(s) are available in our database.

Is 3-Methyl-5-phenyl-2-pentenenitrile allowed in the EU?

3-Methyl-5-phenyl-2-pentenenitrile EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does 3-Methyl-5-phenyl-2-pentenenitrile do in cosmetics?

3-Methyl-5-phenyl-2-pentenenitrile functions as: Perfuming (fragrance ingredient). It is classified as a cosmetic ingredient in our database. CAS number: 93893-89-1.

What is the Margin of Safety for 3-Methyl-5-phenyl-2-pentenenitrile?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for 3-Methyl-5-phenyl-2-pentenenitrile?

The NOAEL (No Observed Adverse Effect Level) for 3-Methyl-5-phenyl-2-pentenenitrile is 50 mg/kg bw/day based on a oral study via oral route in rat. Source: REACH.

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