Is 3-Methyl-5-Propyl-2-Cyclohexenone (Celery Ketone) safe in cosmetics?
3-Methyl-5-Propyl-2-Cyclohexenone (Celery Ketone) has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
GOOD
Cosmetic Ingredient
3-Methyl-5-Propyl-2-Cyclohexenone (Celery Ketone)
INCI: 3-METHYL-5-PROPYL-2-CYCLOHEXENONE
3-Methyl-5-Propyl-2-Cyclohexenone (Celery Ketone) (CAS 3720-16-9) is a cosmetic cosmetic ingredient functioning as Perfuming / Fragrance (celery, herbal note). EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
Function
Perfuming / Fragrance (celery, herbal note)
Editorial assessment
GOOD
Preliminary editorial note — not a computed safety verdict.
Chemistry & Identifiers
IUPAC Name
3-methyl-5-propylcyclohex-2-en-1-one
InChIKey
URQMEZRQHLCJKR-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Not restricted by FDA; also used as a flavoring agent
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for 3-Methyl-5-Propyl-2-Cyclohexenone (Celery Ketone).
Calculate MoS for your specific formulation with the MoS Calculator.
Sensitization AOP Dashboard
Adverse Outcome Pathway data across 5 assays (DPRA, KeratinoSens, hCLAT, LLNA, NESIL) aggregated from public sources.
NESIL
2025 µg/cm²
GHS: 1B
Human: positive
Source: HPPT: [544] RIFM (1981): RIFM report number 1792, November 10, unpublished.
HRIPT Human Patch Test Studies
3 human repeat insult patch tests aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 2025 | - | - |
| HMT | - | 0 | 2025 | - | - |
| HMT | - | 0 | 2025 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1 - 10 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (3)
JECFA Number
1113
Source: WHO/JECFA
JECFA Evaluation
CELERY KETONE | 2002 | No safety concern at current levels of intake when used as a flavouring agent | TRS 913-JECFA 59/95 | FAS 50-JECFA 59/331
Source: WHO/JECFA
JECFA Evaluation
3-METHYL-5-PROPYL-2-CYCLOHEXEN-1-ONE | 2002 | No safety concern at current levels of intake when used as a flavouring agent | TRS 913-JECFA 59/95 | FAS 50-JECFA 59/331
Source: WHO/JECFA
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (3)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Editorial summary
Preliminary editorial summary for 3-Methyl-5-Propyl-2-Cyclohexenone (Celery Ketone) — not a computed safety verdict. See the sourced toxicological data above.
Regulatory Flags
potential-allergen
fragrance-component
ifra_fragrance
fda_food_additive
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
IFRA Transparency
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
consumer_product
Europe
Australian Status
AICIS status: listed
Frequently Asked Questions
Is 3-Methyl-5-Propyl-2-Cyclohexenone (Celery Ketone) allowed in the EU?
3-Methyl-5-Propyl-2-Cyclohexenone (Celery Ketone) EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does 3-Methyl-5-Propyl-2-Cyclohexenone (Celery Ketone) do in cosmetics?
3-Methyl-5-Propyl-2-Cyclohexenone (Celery Ketone) functions as: Perfuming / Fragrance (celery, herbal note). It is classified as a cosmetic ingredient in our database. CAS number: 3720-16-9.
Is 3-Methyl-5-Propyl-2-Cyclohexenone (Celery Ketone) used outside cosmetics?
3-Methyl-5-Propyl-2-Cyclohexenone (Celery Ketone) also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check 3-Methyl-5-Propyl-2-Cyclohexenone (Celery Ketone) compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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3-METHYL-5-PROPYL-2-CYCLOHEXENONE
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