Is 3 O Ethyl Ascorbic Acid safe in cosmetics?
3 O Ethyl Ascorbic Acid has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted.
Excellent
Cosmetic Ingredient
3 O Ethyl Ascorbic Acid
INCI: 3-O-ETHYL ASCORBIC ACID
3 O Ethyl Ascorbic Acid (CAS Insufficient Data) is a cosmetic cosmetic ingredient functioning as Antioxidant; tyrosinase inhibitor; melanogenesis inhibitor; skin-brightening. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS Insufficient Data →
Auto-generated CPSR Part A draft with source citations
Function
Antioxidant; tyrosinase inhibitor; melanogenesis inhibitor; skin-brightening
Safety Rating
EXCELLENT
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted cosmetic ingredient. CIR safe as used (2022 ethers/esters group). No FDA concentration restriction.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for 3 O Ethyl Ascorbic Acid.
Calculate MoS for your specific formulation with the MoS Calculator.
Additional Ingredient Properties
10 property records from structured ingredient metadata.
acne
{"cas_number": "86404-04-8", "anti_acne_mechanism": "anti_inflammatory", "comedogenicity_rating_0_to_5": "0", "acne_type_efficacy": "inflammatory", "sebum_reduction_pct_clinical": "0-10", "prescription_required_usa": "No", "otc_drug_monograph_category": "No", "max_otc_concentration_pct": "No limit", "japan_quasi_drug_anti_acne": "No", "korea_functional_cosmetic_acne": "No", "eu_cosmetic_restrictio…
anti_pollution
{"cas_number": "86404-04-8", "ingredient_class": "antioxidant_pollution_shield", "primary_mechanism": "free_radical_scavenging", "pollution_types_targeted": "PM2_5/UV_A", "IR_A_protection": "no", "visible_light_protection": "no", "digital_screen_protection_claim": "no", "PAH_neutralization": "no", "ozone_protection": "no", "mitochondrial_protection": "no", "Nrf2_activation": "no", "AhR_pathway_mod…
antioxidant
{"cas_number": "86404-04-8", "antioxidant_class": "vitamin", "chemical_subclass": "ethylated ascorbic acid", "molecular_weight_daltons": "204.18", "orac_value_umol_te_per_g": "1800", "dpph_radical_scavenging_ic50_ug_per_ml": "15-28", "abts_trolox_equivalent": "0.8", "singlet_oxygen_quenching": "high", "superoxide_dismutase_mimetic": "moderate", "hydroxyl_radical_scavenging": "high", "lipid_peroxid…
comedogenicity_detail
{"comedogenicity_rating": "0", "irritancy_rating": "1", "skin_type_suitability": "all,oily,combination,normal,mature", "acne_safe": "yes", "source": "Stable vitamin C"}
concentration
{"min_concentration_pct": "1.0", "max_concentration_pct": "2.0", "typical_concentration_pct": "1.5", "product_type": "Moisturizer", "function_at_concentration": "Stable vitamin C", "source": "Supplier TDS"}
interactions
{"ingredient_2": "Retinol", "interaction_type": "synergistic", "severity": "beneficial", "effect": "pH compatible vitamin C derivative, stable with retinol", "recommendation": "One of few vitamin C forms that works well with retinoids", "data_source": "Formulation science literature, dermatological research, cosmetic chemistry best practices", "last_updated": "2026-03-05"}
pregnancy_detail
{"pregnancy_safe": "yes", "breastfeeding_safe": "yes", "risk_category": "not-rated", "reason": "Stable vitamin C derivative; safe", "source": "dermatology literature"}
sensory
{"silky": "powdery", "smooth, glides easily": "smooth, stable", "dry-touch, non-greasy": "brightened, even", "instant": "fast", "low": "low", "w/o": "o/w", "very-high": "excellent", "no": "no", "yes": "no", "1.40": "1.60", "transparent": "opaque", "colorless": "white", "excellent": "excellent", "light": "light", "synthetic": "synthetic"}
Expert Verdict
Expert safety assessment and concern-level summary for 3 O Ethyl Ascorbic Acid.
Regulatory Flags
cir-safe-as-used-2022
eu-unrestricted
superior-stability-ether-bond
amphiphilic
korea-functional-cosmetic-whitening
japan-quasi-drug-whitening
Frequently Asked Questions
Is 3 O Ethyl Ascorbic Acid allowed in the EU?
3 O Ethyl Ascorbic Acid EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does 3 O Ethyl Ascorbic Acid do in cosmetics?
3 O Ethyl Ascorbic Acid functions as: Antioxidant; tyrosinase inhibitor; melanogenesis inhibitor; skin-brightening. It is classified as a cosmetic ingredient in our database. CAS number: Insufficient Data.
Compliance Tools
Check 3 O Ethyl Ascorbic Acid compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
Related Ingredients
1-Methylhydantoin-2-imide (Creatinine)
Excellent
Similar safety
Skin conditioning (skin brightening/l...
2,6-Dimethyl-7-octen-2-ol (Dihydromyrcenol)
Excellent
Similar safety
Fragrance (perfuming), masking
2-Ethoxy-2,6,6-Trimethyl-9-Methylenebicyclo[3.3.1]Nonane (Boisiris™)
Excellent
Similar safety
Fragrance (rich woody, orris/iris roo...
2-Hydroxypropylcarbamato Amodimethicone
Excellent
Similar safety
Hair conditioning; modified aminosili...
2-O-Ethyl Ascorbic Acid
Excellent
Similar safety
Softener and conditioner
3,6-Dimethyl-3-Octyl Acetate
Excellent
Similar safety
Fragrance / Perfuming agent with flor...
3,3,5-Trimethylcyclohexyl Succinate Dimethylamide
Good
Browse nearby
Skin conditioning agent
3,3-Dimethyl-1,5-Dioxaspiro-Undecane
Good
Browse nearby
Fragrance / Perfuming
3,4-DIHYDROXYBENZOIC ACID
Good
Browse nearby
Skin Protecting
3,4-Diaminobenzoic Acid
Poor
Browse nearby
Hair dye precursor (oxidative)
(20S)-Protopanaxadiol
Moderate
Same EU status
(AGARICUS BLAZEI FERMENT + GANODERMA LUCIDUM FERMENT + GANODERMA MULTIPILEUM FERMENT) EXTRACT
Good
Same EU status
Anti-sebum, Antioxidant, Skin Protecting
(ANGELICA ACUTILOBA/PAEONIA LACTIFLORA/REHMANNIA GLUTINOSA) ROOT/CNIDIUM OFFICINALE RHIZOME EXTRACT
Good
Same EU status
Skin Conditioning, Skin Conditioning ...
(ANGELICA ACUTILOBA/PAEONIA LACTIFLORA/REHMANNIA GLUTINOSA/SCUTELLARIA BAICALENSIS) ROOT/(CNIDIUM OFFICINALE/COPTIS CHINENSIS) RHIZOME/GARDENIA JASMINOIDES FRUIT/PHELLODENDRON CHINENSE BARK EXTRACT
Good
Same EU status
Is 3 O Ethyl Ascorbic Acid in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for 3 O Ethyl Ascorbic Acid in your formulation.