Good Cosmetic Ingredient NOAEL Data

3-Octanol

INCI: 3-OCTANOL

CAS Number
589-98-0
Function
Fragrance
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted โ€” FEMA GRAS status; no FDA-specific cosmetic restriction

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

1 study endpoint found for 3-Octanol. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 25 mg/kg bw/day oral rat oral REACH

Expert Verdict

Fragrance ingredient with adequate margin of safety; mild skin irritation possible at elevated concentrations per IFRA guidance.

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Concern Level: Low

Regulatory Flags

fragrance-component ifra_fragrance fda_food_additive jecfa_safe

Frequently Asked Questions

Is 3-Octanol safe in cosmetics?

Fragrance ingredient with adequate margin of safety; mild skin irritation possible at elevated concentrations per IFRA guidance. The EU classifies 3-Octanol as "permitted". Safety rating: GOOD. 1 toxicological study endpoint(s) are available in our database.

Is 3-Octanol allowed in the EU?

3-Octanol EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does 3-Octanol do in cosmetics?

3-Octanol functions as: Fragrance. It is classified as a cosmetic ingredient in our database. CAS number: 589-98-0.

What is the Margin of Safety for 3-Octanol?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for 3-Octanol?

The NOAEL (No Observed Adverse Effect Level) for 3-Octanol is 25 mg/kg bw/day based on a oral study via oral route in rat. Source: REACH.

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