Is 4-Methyl-1-Oxaspiroundecene safe in cosmetics?
4-Methyl-1-Oxaspiroundecene has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
4-Methyl-1-Oxaspiroundecene
Also known as: EINECS 269-401-8, 1-Oxaspiro(5.5)undec-4-ene, 4-methyl
INCI: 4-METHYL-1-OXASPIROUNDECENE
4-Methyl-1-Oxaspiroundecene (CAS 68228-06-8) is a cosmetic cosmetic ingredient functioning as Fragrance (perfuming). EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 68228-06-8 →
Auto-generated CPSR Part A draft with source citations
Function
Fragrance (perfuming)
Safety Rating
GOOD
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Not specifically regulated; falls under general fragrance classification per FDA
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for 4-Methyl-1-Oxaspiroundecene.
Calculate MoS for your specific formulation with the MoS Calculator.
Sensitization AOP Dashboard
Adverse Outcome Pathway data across 5 assays (DPRA, KeratinoSens, hCLAT, LLNA, NESIL) aggregated from public sources.
NESIL
837 µg/cm²
GHS: 1B
Human: positive
Source: HPPT: [712] RIFM (1975): RIFM report number 54559, unpublished.
HRIPT Human Patch Test Studies
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HRIPT | - | 0 | 837 | - | - |
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Fragrance
Regulatory List Membership (2)
IFRA Fragrance Transparency List
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for 4-Methyl-1-Oxaspiroundecene.
Regulatory Flags
potential-allergen
fragrance-component
ifra_fragrance
Known Synonyms
EINECS 269-401-8
1-Oxaspiro(5.5)undec-4-ene, 4-methyl
Chemical Function
Fragrance
Regulatory Lists
IFRA Transparency
consumer_product
Australian Status
AICIS status: listed
Frequently Asked Questions
Is 4-Methyl-1-Oxaspiroundecene allowed in the EU?
4-Methyl-1-Oxaspiroundecene EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does 4-Methyl-1-Oxaspiroundecene do in cosmetics?
4-Methyl-1-Oxaspiroundecene functions as: Fragrance (perfuming). It is classified as a cosmetic ingredient in our database. CAS number: 68228-06-8.
Compliance Tools
Check 4-Methyl-1-Oxaspiroundecene compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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