Is 4-METHYLPENTAN-2-OL safe in cosmetics?
4-METHYLPENTAN-2-OL has a safety rating of "GOOD" in our database. EU status: permitted.
4-METHYLPENTAN-2-OL
Also known as: M.I.B.C., 4-01-00-01717, BRN 1098268, 1,3-Dimethylbutanol, EINECS 203-551-7 (+10 more)
4-METHYLPENTAN-2-OL (CAS 108-11-2) is a cosmetic cosmetic ingredient functioning as Perfuming. NOAEL 30 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 108-11-2 →
Auto-generated CPSR Part A draft with source citations
Regulatory Status
EU EU Status
permitted
US US Status
Not specifically regulated
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Short-term Exposure Effects
The substance is irritating to the eyes, skin and respiratory tract. Exposure could cause lowering of consciousness.
Long-term Exposure Effects
The substance defats the skin, which may cause dryness or cracking.
Routes of Exposure
The substance can be absorbed into the body by inhalation of its vapour and through the skin.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for 4-METHYLPENTAN-2-OL across SCCS product categories, with measured dermal absorption where available.
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Warning
Pictograms
FlammableHarmful / Irritant
Hazard Class and Category
Flam. Liq. 3; STOT SE 3
Hazard Statements
- H226 Flammable liquid and vapour
- H335 May cause respiratory irritation
Specific Concentration Limits / M-factors
STOT SE 3; H335: C ≥ 25.0%
Inserted via ATP: CLP00
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Chemical reaction regulator
Flavouring and nutrient
Fragrance
Solvent
Regulatory List Membership (2)
IFRA Fragrance Transparency List
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for 4-METHYLPENTAN-2-OL.
Regulatory Flags
cosing-sourced
eu-permitted
fragrance
needs-enrichment
ifra_fragrance
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to 4-METHYLPENTAN-2-OL by CAS number or substance name.
Studies
9
Lowest NOAEL
30 mg/kg bw/day
Highest NOAEL
300 mg/kg bw/day
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip
Known Synonyms
M.I.B.C.
4-01-00-01717
BRN 1098268
1,3-Dimethylbutanol
EINECS 203-551-7
Methylisobutyl carbinol
4-Methylpentanol-2
4-Pentanol, 2-methyl-
(+-)-4-Methyl-2-pentanol
4-Metilpentan-2-olo
Alcohol methyl amylique
Alcool methyl amylique
Methyl-isobutylkarbinol
Metilamil alcohol
UNII-8U34XJK0R0
Chemical Function
Fragrance
Flavouring and nutrient
Solvent
Chemical reaction regulator
Regulatory Lists
air; detected; emissions; Europe; Other direct contact consumer goods
IFRA Transparency
consumer_product
Europe
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL448896
Frequently Asked Questions
Is 4-METHYLPENTAN-2-OL allowed in the EU?
4-METHYLPENTAN-2-OL EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does 4-METHYLPENTAN-2-OL do in cosmetics?
4-METHYLPENTAN-2-OL functions as: Perfuming. It is classified as a cosmetic ingredient in our database. CAS number: 108-11-2.
Is 4-METHYLPENTAN-2-OL used outside cosmetics?
4-METHYLPENTAN-2-OL also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check 4-METHYLPENTAN-2-OL compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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