Good Cosmetic Ingredient NOAEL Data

4-Phenylpropylpyridine

INCI: 4-PHENYLPROPYLPYRIDINE

CAS Number
2057-49-0
Function
Perfuming / fragrance ingredient
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted; no specific FDA restrictions on this fragrance ingredient

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

1 study endpoint found for 4-Phenylpropylpyridine. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 30 mg/kg bw/day oral rat oral REACH

Expert Verdict

Limited publicly available toxicological data; should be used within IFRA concentration limits

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Concern Level: Low

Regulatory Flags

fragrance-component ifra_fragrance

Frequently Asked Questions

Is 4-Phenylpropylpyridine safe in cosmetics?

Limited publicly available toxicological data; should be used within IFRA concentration limits The EU classifies 4-Phenylpropylpyridine as "permitted". Safety rating: GOOD. 1 toxicological study endpoint(s) are available in our database.

Is 4-Phenylpropylpyridine allowed in the EU?

4-Phenylpropylpyridine EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does 4-Phenylpropylpyridine do in cosmetics?

4-Phenylpropylpyridine functions as: Perfuming / fragrance ingredient. It is classified as a cosmetic ingredient in our database. CAS number: 2057-49-0.

What is the Margin of Safety for 4-Phenylpropylpyridine?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for 4-Phenylpropylpyridine?

The NOAEL (No Observed Adverse Effect Level) for 4-Phenylpropylpyridine is 30 mg/kg bw/day based on a oral study via oral route in rat. Source: REACH.

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