Is 4-Phenylpropylpyridine safe in cosmetics?
4-Phenylpropylpyridine has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted. 1 toxicological study endpoint(s) are available in our database.
4-Phenylpropylpyridine
Also known as: Pyridine, 4-(3-phenylpropyl)-, EINECS 218-159-1
INCI: 4-PHENYLPROPYLPYRIDINE
4-Phenylpropylpyridine (CAS 2057-49-0) is a cosmetic cosmetic ingredient functioning as Perfuming / fragrance ingredient. NOAEL 30 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 2057-49-0 →
Auto-generated CPSR Part A draft with source citations
Function
Perfuming / fragrance ingredient
Safety Rating
GOOD
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted; no specific FDA restrictions on this fragrance ingredient
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for 4-Phenylpropylpyridine.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
1 study endpoint found for 4-Phenylpropylpyridine. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =30 mg/kg bw/day | oral | Rat | subchronic | ToxValDB_ECHA_IUCLID |
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for 4-Phenylpropylpyridine across SCCS product categories, with measured dermal absorption where available.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Fragrance
Regulatory List Membership (1)
IFRA Fragrance Transparency List
Expert Verdict
Expert safety assessment and concern-level summary for 4-Phenylpropylpyridine.
Regulatory Flags
fragrance-component
ifra_fragrance
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to 4-Phenylpropylpyridine by CAS number or substance name.
Studies
1
Lowest NOAEL
30 mg/kg bw/day
Highest NOAEL
30 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Known Synonyms
Pyridine, 4-(3-phenylpropyl)-
EINECS 218-159-1
Chemical Function
Fragrance
Regulatory Lists
IFRA Transparency
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3186973
Frequently Asked Questions
Is 4-Phenylpropylpyridine allowed in the EU?
4-Phenylpropylpyridine EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does 4-Phenylpropylpyridine do in cosmetics?
4-Phenylpropylpyridine functions as: Perfuming / fragrance ingredient. It is classified as a cosmetic ingredient in our database. CAS number: 2057-49-0.
What is the NOAEL for 4-Phenylpropylpyridine?
The NOAEL (No Observed Adverse Effect Level) for 4-Phenylpropylpyridine is =30 mg/kg bw/day based on a subchronic study via oral route in Rat. Source: ToxValDB_ECHA_IUCLID.
Is 4-Phenylpropylpyridine used outside cosmetics?
4-Phenylpropylpyridine also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check 4-Phenylpropylpyridine compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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