5-Amino-4-Chloro-o-Cresol

INCI: 5-AMINO-4-CHLORO-O-CRESOL

CAS Number
110102-86-8
Function
Hair colorant (oxidative hair dye precursor)
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status restricted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes CIR concluded safe for oxidative hair dyes (Dec 2023); classified as coal tar hair dye requiring caution labeling and patch test instructions per FD&C Act

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
low
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Mutagenic in Ames TA98 with metabolic activation; tertiary amine prone to nitrosation โ€” must not combine with nitrosating agents; no current reported uses per 2023 VCRP

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Concern Level: Moderate

Regulatory Flags

colorant

Frequently Asked Questions

Is 5-Amino-4-Chloro-o-Cresol safe in cosmetics?

Mutagenic in Ames TA98 with metabolic activation; tertiary amine prone to nitrosation โ€” must not combine with nitrosating agents; no current reported uses per 2023 VCRP The EU classifies 5-Amino-4-Chloro-o-Cresol as "restricted". Safety rating: MODERATE.

Is 5-Amino-4-Chloro-o-Cresol allowed in the EU?

5-Amino-4-Chloro-o-Cresol EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.

What does 5-Amino-4-Chloro-o-Cresol do in cosmetics?

5-Amino-4-Chloro-o-Cresol functions as: Hair colorant (oxidative hair dye precursor). It is classified as a cosmetic ingredient in our database. CAS number: 110102-86-8.

What is the Margin of Safety for 5-Amino-4-Chloro-o-Cresol?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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