Is 5-Cyclohexadecenone safe in cosmetics?
5-Cyclohexadecenone has a safety rating of "GOOD" in our database. EU status: restricted. US status: permitted.
Good
Cosmetic Ingredient
5-Cyclohexadecenone
Also known as: Toray-musk, Globanone, EINECS 253-568-9
INCI: 5-CYCLOHEXADECENONE
5-Cyclohexadecenone (CAS 37609-25-9) is a cosmetic cosmetic ingredient functioning as Fragrance (synthetic macrocyclic musk; trade names: Ambretone, Velvione, TM-II). EU Regulation 1223/2009 status: restricted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 37609-25-9 →
Auto-generated CPSR Part A draft with source citations
Function
Fragrance (synthetic macrocyclic musk; trade names: Ambretone, Velvione, TM-II)
Safety Rating
GOOD
Regulatory Status
EU EU Status
restricted
US US Status
permitted
US Notes
No specific FDA restriction; IFRA-regulated fragrance ingredient
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for 5-Cyclohexadecenone.
Calculate MoS for your specific formulation with the MoS Calculator.
HRIPT Human Patch Test Studies
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HRIPT | - | 0 | - | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Fragrance
Regulatory List Membership (2)
IFRA Fragrance Transparency List
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for 5-Cyclohexadecenone.
Regulatory Flags
fragrance-component
natural-origin
ifra_fragrance
Known Synonyms
Toray-musk
Globanone
EINECS 253-568-9
Chemical Function
Fragrance
Regulatory Lists
IFRA Transparency
consumer_product
Australian Status
AICIS status: listed
Frequently Asked Questions
Is 5-Cyclohexadecenone allowed in the EU?
5-Cyclohexadecenone EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
What does 5-Cyclohexadecenone do in cosmetics?
5-Cyclohexadecenone functions as: Fragrance (synthetic macrocyclic musk; trade names: Ambretone, Velvione, TM-II). It is classified as a cosmetic ingredient in our database. CAS number: 37609-25-9.
Is 5-Cyclohexadecenone used outside cosmetics?
5-Cyclohexadecenone also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check 5-Cyclohexadecenone compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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