5-Cyclohexadecenone

INCI: 5-CYCLOHEXADECENONE

CAS Number
37609-25-9
Function
Fragrance (synthetic macrocyclic musk; trade names: Ambretone, Velvione, TM-II)
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status restricted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes No specific FDA restriction; IFRA-regulated fragrance ingredient

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Considered a safer musk alternative versus nitro musks and polycyclic musks; used as a substitute for natural musk (civetone/muscone)

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Concern Level: Low

Regulatory Flags

fragrance-component natural-origin ifra_fragrance

Frequently Asked Questions

Is 5-Cyclohexadecenone safe in cosmetics?

Considered a safer musk alternative versus nitro musks and polycyclic musks; used as a substitute for natural musk (civetone/muscone) The EU classifies 5-Cyclohexadecenone as "restricted". Safety rating: GOOD.

Is 5-Cyclohexadecenone allowed in the EU?

5-Cyclohexadecenone EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.

What does 5-Cyclohexadecenone do in cosmetics?

5-Cyclohexadecenone functions as: Fragrance (synthetic macrocyclic musk; trade names: Ambretone, Velvione, TM-II). It is classified as a cosmetic ingredient in our database. CAS number: 37609-25-9.

What is the Margin of Safety for 5-Cyclohexadecenone?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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