Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Expert Verdict
If used as a preservative, requires Annex V listing in EU; metal-chelating properties may interfere with formulation stability; limited toxicological dataset compared to β-thujaplicin.
Frequently Asked Questions
Is 5-Isopropyltropolone safe in cosmetics?
If used as a preservative, requires Annex V listing in EU; metal-chelating properties may interfere with formulation stability; limited toxicological dataset compared to β-thujaplicin. The EU classifies 5-Isopropyltropolone as "prohibited". Safety rating: MODERATE.
Is 5-Isopropyltropolone allowed in the EU?
5-Isopropyltropolone EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does 5-Isopropyltropolone do in cosmetics?
5-Isopropyltropolone functions as: Antimicrobial / Skin Conditioning — tropolone derivatives exhibit broad-spectrum antimicrobial activity. It is classified as a cosmetic ingredient in our database. CAS number: 618-78-0 (γ-thujaplicin; distinct from hinokitiol/β-thujaplicin, CAS 499-44-5, which is 4-isopropyltropolone).
What is the Margin of Safety for 5-Isopropyltropolone?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
Compliance Tools
Check 5-Isopropyltropolone compliance across multiple jurisdictions:
Related Ingredients
Is 5-Isopropyltropolone in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for 5-Isopropyltropolone in your formulation.