6-Isobutylquinoline

INCI: 6-ISOBUTYLQUINOLINE

CAS Number
68198-80-1
Function
Fragrance with intense leathery-animalic, tobacco, and woody notes
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted under general fragrance framework; no specific FDA restrictions. On the IFRA Transparency List.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Very high odor intensity typically dosed below 1%; quinoline scaffold has known toxicological concerns in related derivatives and specific safety of the 6-isobutyl derivative should be confirmed via RIFM monograph before use.

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Concern Level: High

Regulatory Flags

fragrance-component ifra_fragrance

Frequently Asked Questions

Is 6-Isobutylquinoline safe in cosmetics?

Very high odor intensity typically dosed below 1%; quinoline scaffold has known toxicological concerns in related derivatives and specific safety of the 6-isobutyl derivative should be confirmed via RIFM monograph before use. The EU classifies 6-Isobutylquinoline as "permitted". Safety rating: MODERATE.

Is 6-Isobutylquinoline allowed in the EU?

6-Isobutylquinoline EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does 6-Isobutylquinoline do in cosmetics?

6-Isobutylquinoline functions as: Fragrance with intense leathery-animalic, tobacco, and woody notes. It is classified as a cosmetic ingredient in our database. CAS number: 68198-80-1.

What is the Margin of Safety for 6-Isobutylquinoline?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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