Is 8-Hydroxydaidzein safe in cosmetics?
8-Hydroxydaidzein has a safety rating of "MODERATE" in our database. EU status: prohibited. US status: restricted.
MODERATE
Cosmetic Ingredient
8-Hydroxydaidzein
Also known as: UNII-PLM2K574GE, 6,7,4'-trihydroxyisoflavone, 6-Hydroxydaidzein
INCI: 8-HYDROXYDAIDZEIN
8-Hydroxydaidzein (CAS 17817-31-1) is a cosmetic cosmetic ingredient functioning as Skin conditioning, skin whitening/depigmenting. EU Regulation 1223/2009 status: prohibited, max 0.02%. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in pharmaceutical data.
View industrial chemical safety profile for CAS 17817-31-1 →
Function
Skin conditioning, skin whitening/depigmenting
Editorial assessment
MODERATE
Preliminary editorial note — not a computed safety verdict.
Regulatory Status
EU EU Status
prohibited
EU Max Conc.
0.02%
US US Status
restricted
US Notes
Not specifically restricted by FDA; no OTC monograph for skin lightening with this ingredient
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for 8-Hydroxydaidzein.
Calculate MoS for your specific formulation with the MoS Calculator.
Editorial summary
Preliminary editorial summary for 8-Hydroxydaidzein — not a computed safety verdict. See the sourced toxicological data above.
Known Synonyms
UNII-PLM2K574GE
6,7,4'-trihydroxyisoflavone
6-Hydroxydaidzein
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL239156
Frequently Asked Questions
Is 8-Hydroxydaidzein allowed in the EU?
8-Hydroxydaidzein EU regulatory status: prohibited. Maximum allowed concentration: 0.02%. This is based on EU Regulation 1223/2009 and its amendments.
What does 8-Hydroxydaidzein do in cosmetics?
8-Hydroxydaidzein functions as: Skin conditioning, skin whitening/depigmenting. It is classified as a cosmetic ingredient in our database. CAS number: 17817-31-1.
Is 8-Hydroxydaidzein used outside cosmetics?
8-Hydroxydaidzein also appears in pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check 8-Hydroxydaidzein compliance across multiple jurisdictions:
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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