8-Hydroxydaidzein

INCI: 8-HYDROXYDAIDZEIN

CAS Number
17817-31-1
Function
Skin conditioning, skin whitening/depigmenting
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status prohibited
EU Max Conc. 0.02%
๐Ÿ‡บ๐Ÿ‡ธ US Status restricted
US Notes Not specifically restricted by FDA; no OTC monograph for skin lightening with this ingredient

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Endocrine disruption concern due to phytoestrogen activity with potency >10ร— greater than kojic acid in tyrosinase inhibition; SCCS found insufficient data on daidzein-class risk assessment; not approved in all markets for skin-lightening claims.

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Concern Level: High

Frequently Asked Questions

Is 8-Hydroxydaidzein safe in cosmetics?

Endocrine disruption concern due to phytoestrogen activity with potency >10ร— greater than kojic acid in tyrosinase inhibition; SCCS found insufficient data on daidzein-class risk assessment; not approved in all markets for skin-lightening claims. The EU classifies 8-Hydroxydaidzein as "prohibited". Safety rating: MODERATE.

Is 8-Hydroxydaidzein allowed in the EU?

8-Hydroxydaidzein EU regulatory status: prohibited. Maximum allowed concentration: 0.02%. This is based on EU Regulation 1223/2009 and its amendments.

What does 8-Hydroxydaidzein do in cosmetics?

8-Hydroxydaidzein functions as: Skin conditioning, skin whitening/depigmenting. It is classified as a cosmetic ingredient in our database. CAS number: 17817-31-1.

What is the Margin of Safety for 8-Hydroxydaidzein?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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