Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
1 study endpoint found for Dimethyl Carbonate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOEL | >500 mg/kg bw/day | oral | rat | oral | REACH |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Expert Verdict
CIR Expert Panel concluded dialkyl carbonates are safe in current practices when formulated to be non-irritating. At ≥75% dermal concentration, significant thymus weight decrease observed indicating immunotoxicity signal. Acute inhalation LC50 = 0.14 g/L (4h, rat) is relevant for aerosol and spray products. Flammable with propellant classification.
Frequently Asked Questions
Is Dimethyl Carbonate safe in cosmetics?
CIR Expert Panel concluded dialkyl carbonates are safe in current practices when formulated to be non-irritating. At ≥75% dermal concentration, significant thymus weight decrease observed indicating immunotoxicity signal. Acute inhalation LC50 = 0.14 g/L (4h, rat) is relevant for aerosol and spray products. Flammable with propellant classification. The EU classifies Dimethyl Carbonate as "prohibited". Safety rating: MODERATE. 1 toxicological study endpoint(s) are available in our database.
Is Dimethyl Carbonate allowed in the EU?
Dimethyl Carbonate EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Dimethyl Carbonate do in cosmetics?
Dimethyl Carbonate functions as: Solvent. It is classified as a cosmetic ingredient in our database. CAS number: 616-38-6.
What is the Margin of Safety for Dimethyl Carbonate?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Dimethyl Carbonate?
The NOAEL (No Observed Adverse Effect Level) for Dimethyl Carbonate is >500 mg/kg bw/day based on a oral study via oral route in rat. Source: REACH.
Compliance Tools
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Related Ingredients
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