Is Acid Blue 62 safe in cosmetics?
Acid Blue 62 has a safety rating of "GOOD" in our database. EU status: restricted. US status: prohibited. 10 toxicological study endpoint(s) are available in our database.
Acid Blue 62
Also known as: 2-Anthracenesulfonic acid, 1-amino-4-(cyclohexylamino)-9,10-dihydro-9,10-dioxo-, monosodium salt, C.I. 62045, 2-Anthracenesulfonic acid, 1-amino-4-(cyclohexylamino)-9,10-dihydro-9,10-dioxo-, sodium salt (1:1), 1-Amino-4-cyclohexylaminoanthraquinone-2-sodium sulfonate, Lerui Acid Brilliant Blue P 3FRL (+15 more)
INCI: CI 62045
Acid Blue 62 (CAS 4368-56-3) is a cosmetic cosmetic ingredient functioning as Colorant, Hair dyeing. Reported NOAEL =300 mg/kg bw/day in rat (SCCNFP Opinion); EU Regulation 1223/2009 status: restricted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
Cross-Vertical Regulatory Divergence
Acid Blue 62 is classified GHS CMR hazard (H319, H341, H412, H413) in the chemicals database but is restricted in EU cosmetics.
Source: Cosmetics: ingredients.eu status; Chemicals: ghs classifications.signal word/hazard statement code
Function
Colorant, Hair dyeing
Editorial assessment
GOOD
Preliminary editorial note — not a computed safety verdict.
Chemistry & Identifiers
IUPAC Name
sodium 1-amino-4-(cyclohexylamino)-9,10-dioxoanthracene-2-sulfonate
InChIKey
DJDYMAHXZBQZKH-UHFFFAOYSA-M
Regulatory Status
EU EU Status
restricted
US US Status
prohibited
US Notes
Not FDA-approved as a color additive for cosmetics
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Acid Blue 62.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for Acid Blue 62. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =300 mg/kg bw/day | - | rat | developmental toxicity | SCCNFP Opinion |
| NOAEL | =300 mg/kg bw/day | - | rat | developmental toxicity | SCCNFP Opinion |
| NOAEL | =300 mg/kg bw/day | - | rat | developmental toxicity | SCCNFP Opinion |
| NOAEL | =300 mg/kg bw/day | - | rat | developmental toxicity | SCCNFP Opinion |
| NOAEL | =160 mg/kg | oral | rat | repeated dose toxicity | SCCS Opinion |
| NOAEL | =160 mg/kg | oral | rat | repeated dose toxicity | SCCS Opinion |
| NOAEL | =160 mg/kg | oral | rat | repeated dose toxicity | SCCS Opinion |
| NOAEL | =160 mg/kg | oral | rat | repeated dose toxicity | SCCS Opinion |
| NOAEL | =300 mg/kg bw/day | - | rat | developmental toxicity | SCCS Opinion |
| NOAEL | =300 mg/kg bw/day | - | rat | developmental toxicity | SCCS Opinion |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1 - 10 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
EU CosIng Annex Listing
European Commission CosIng database Annex references per Regulation (EC) No 1223/2009.
Annex IV — Permitted Colorants
Product type: Blue
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (III - Restricted)
Product type: Hair dye substance in non-oxidative hair dye products. Max: 0.005.
BRIN Brazil/India Cosmetics
India: Restricted · max 0.005
India: Permitted Colorant
Expanded Dermal Absorption Data
Cross-database dermal penetration: EPA Dryad physics-based, Roberts Mendeley permeation, and SCCS-aggregated measured values.
Aggregated DA Values (2 records across 5 sources)
| Type | DA % | Method | Skin Model | SCCS Ref |
|---|---|---|---|---|
| measured_sccs_opinion | 0.26% | - | - | SCCP/0878 |
| measured_sccs_opinion | 100.0% | - | - | SCCP/0878/05 |
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Dye
Regulatory List Membership (2)
EU Regulated in Personal Care
EU CosIng Cosmetics Ingredient Database
Editorial summary
Preliminary editorial summary for Acid Blue 62 — not a computed safety verdict. See the sourced toxicological data above.
Regulatory Flags
colorant
eu_cosing_listed
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Acid Blue 62 by CAS number or substance name.
Studies
12
Lowest NOAEL
160
Highest NOAEL
300
Units vary across source rows: mg/kg, mg/kg bw/day
SCCS Opinion
SCCNFP Opinion
Dermal Absorption
View details ->| Absorption % | Method | Vehicle |
|---|---|---|
| 0.26% | SCCS opinion extraction | - |
| 100.0% | SCCS opinion extraction | - |
Known Synonyms
2-Anthracenesulfonic acid, 1-amino-4-(cyclohexylamino)-9,10-dihydro-9,10-dioxo-, monosodium salt
C.I. 62045
2-Anthracenesulfonic acid, 1-amino-4-(cyclohexylamino)-9,10-dihydro-9,10-dioxo-, sodium salt (1:1)
1-Amino-4-cyclohexylaminoanthraquinone-2-sodium sulfonate
Lerui Acid Brilliant Blue P 3FRL
Lissamine Blue 2BR
Midlon Blue 2R
Naphthazine Blue CRFF
Sodium 1-amino-4-(cyclohexylamino)-2-anthraquinonesulfonate
Vicoacid Blue 62
Vopsider Blue AIR
Weak Acid Brilliant Blue 2BR
Acid Alizarine Pure Blue R
Alizarine brilliant sapphire R
Alizarine Brilliant Sky Blue R
Alizarine Direct Pure Blue R
Alizarine Fast Blue RFE
Alizarine Sky Blue R
Alizarine Supra Blue R
Alizarine Supra Sky RA
Chemical Function
Dye
Regulatory Lists
inert_ingredient; non_food_use; Pesticides
Europe; Personal care
Europe; Personal care; restricted
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL606414
Frequently Asked Questions
Is Acid Blue 62 allowed in the EU?
Acid Blue 62 EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
What does Acid Blue 62 do in cosmetics?
Acid Blue 62 functions as: Colorant, Hair dyeing. It is classified as a cosmetic ingredient in our database. CAS number: 4368-56-3.
What is the NOAEL for Acid Blue 62?
The NOAEL (No Observed Adverse Effect Level) for Acid Blue 62 is =300 mg/kg bw/day based on a developmental toxicity study via oral route in rat. A total of 10 study endpoints are available. Source: SCCNFP Opinion.
Is Acid Blue 62 used outside cosmetics?
Acid Blue 62 also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Acid Blue 62 have different safety status in cosmetics vs industrial chemicals?
Acid Blue 62 is classified GHS CMR hazard (H319, H341, H412, H413) in the chemicals database but is restricted in EU cosmetics.
Compliance Tools
Check Acid Blue 62 compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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