Good Cosmetic Ingredient NOAEL Data

Acid Yellow 23

INCI: CI 19140

CAS Number
1934-21-0
Function
Colorant (monoazo dye; Tartrazine)
Safety Rating
GOOD

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes FD&C Yellow No. 5 — permanently listed, certification required; food, drugs, and cosmetics generally

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
negligible
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

10 study endpoints found for Acid Yellow 23. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 750 mg/kg bw/day oral rat Chronic COSMOS_DB
NOAEL 750 mg/kg bw/day oral rat Multigeneration Reproductive COSMOS_DB
NOAEL 1000 mg/kg bw/day oral rabbit Developmental COSMOS_DB
NOAEL 1000 mg/kg bw/day oral rat Developmental COSMOS_DB
NOAEL 2500 mg/kg bw/day oral rat Chronic COSMOS_DB
NOAEL 2500 mg/kg bw/day oral rat Carcinogenicity COSMOS_DB
NOAEL 1500 mg/kg bw/day oral dog Chronic COSMOS_DB
NOAEL 2641 mg/kg bw/day oral rat Carcinogenicity COSMOS_DB
NOAEL 984 mg/kg bw/day oral rat Carcinogenicity COSMOS_DB
NOAEL 7500 mg/kg bw/day oral mouse Chronic COSMOS_DB

Expert Verdict

Mandatory declaration on US food labels; cross-reactivity with aspirin; azo dye but no evidence of hazardous aromatic amine release under normal conditions

⚠️
Concern Level: Low

Regulatory Flags

colorant eu_children_restricted epa_safer_alternative ifra_fragrance fda_food_additive

Frequently Asked Questions

Is Acid Yellow 23 safe in cosmetics?

Mandatory declaration on US food labels; cross-reactivity with aspirin; azo dye but no evidence of hazardous aromatic amine release under normal conditions The EU classifies Acid Yellow 23 as "permitted". Safety rating: GOOD. 10 toxicological study endpoint(s) are available in our database.

Is Acid Yellow 23 allowed in the EU?

Acid Yellow 23 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Acid Yellow 23 do in cosmetics?

Acid Yellow 23 functions as: Colorant (monoazo dye; Tartrazine). It is classified as a cosmetic ingredient in our database. CAS number: 1934-21-0.

What is the Margin of Safety for Acid Yellow 23?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Acid Yellow 23?

The NOAEL (No Observed Adverse Effect Level) for Acid Yellow 23 is 750 mg/kg bw/day based on a Chronic study via oral route in rat. A total of 10 study endpoints are available. Source: COSMOS_DB.

Compliance Tools

Check Acid Yellow 23 compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
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Substance Compliance
Check compliance across 55 jurisdictions
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
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Heavy Metal Limits
Compare limits across jurisdictions

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