Is CI 19140 safe in cosmetics?
CI 19140 has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted. 10 toxicological study endpoint(s) are available in our database.
CI 19140
Also known as: 1H-Pyrazole-3-carboxylic acid, 4,5-dihydro-5-oxo-1-(4-sulfophenyl)-4-[(4-sulfophenyl)azo]-, trisodium salt, C.I. 19140, Tartrazine, Tartrazine yellow 19140, D&C Yellow 5 (+15 more)
CI 19140 (CAS 1934-21-0) is a cosmetic cosmetic ingredient functioning as Colorant. NOAEL 1 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety, pharmaceutical, and food safety data.
Cross-Vertical Regulatory Divergence
CI 19140 is classified GHS Danger (H317, H334) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu status; Chemicals: ghs classifications.signal word/hazard statement code
Function
Colorant
Editorial assessment
GOOD
Preliminary editorial note — not a computed safety verdict.
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
FDA-approved as FD&C Yellow No. 5; permitted for use in all cosmetics including lip products and eye-area products when conforming to FDA specs; batch certification required; 21 CFR 74.1705
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for CI 19140.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for CI 19140. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 500 mg/kg bw/day | oral | rat | Neurotoxicity | COSMOS DB |
| NOAEL | 750 mg/kg bw/day | oral | rat | Chronic | COSMOS DB |
| NOAEL | 773 mg/kg bw/day | oral | mouse | Reproductive | COSMOS DB |
| NOAEL | 1064 mg/kg bw/day | oral | rat | Developmental | COSMOS DB |
| NOAEL | 1105 mg/kg bw/day | oral | rat | Chronic | COSMOS DB |
| NOAEL | 1500 mg/kg bw/day | oral | dog | Chronic | COSMOS DB |
| NOAEL | 2190 mg/kg bw/day | oral | rat | Carcinogenicity | COSMOS DB |
| NOAEL | 2418 mg/kg bw/day | oral | mouse | Chronic | COSMOS DB |
| NOAEL | 2500 mg/kg bw/day | oral | rat | Chronic | COSMOS DB |
| NOAEL | 2995 mg/kg bw/day | oral | rat | Chronic | COSMOS DB |
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for CI 19140 across SCCS product categories, with measured dermal absorption where available.
EPA ToxValDB — Toxicity Values
10 toxicity values from EPA ToxValDB (aggregated from CCTE, HPV, ToxRefDB, IRIS, and other regulatory dossiers).
| Endpoint | Value | Species | Route | Duration | Source |
|---|---|---|---|---|---|
| NOAEL | =1064.3 mg/kg-day | Rat | oral | - | ECHA |
| NOAEL | =642.8 mg/kg-day | Mouse | oral | - | ECHA |
| NOAEL | =1064.3 mg/kg-day | Rat | oral | - | ECHA |
| NOAEL | =1250 mg/kg-day | Rat | oral | subchronic | ECHA |
| NOAEL | =1250 mg/kg-day | Rat | oral | subchronic | ECHA |
| NOAEL | =1000 mg/kg-day | Rat | oral | - | ECHA |
| NOAEL | =1000 mg/kg-day | Rat | oral | - | ECHA |
| NOAEL | =1000 mg/kg-day | Rat | oral | - | ECHA |
| NOAEL | =1000 mg/kg-day | Rat | oral | - | ECHA |
| NOAEL | =1064.3 mg/kg-day | Rat | oral | - | ECHA |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
Additional Jurisdictional Restrictions (5)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| CN | permitted_hair_dye | 0.5 | Non-oxidative hair dye |
| CN | permitted_colorant | - | All cosmetics (Class 1) |
| BR | permitted_colorant | - | Column 2: All products except eye area |
| ASEAN | restricted | 0.5% | Non-oxidative hair dye products only |
| ASEAN | permitted_colorant | - | All products (0.5% limit in non-oxidative hair dye — Annex III) |
Typical Use Concentrations
Reported concentration ranges per product category from SCCS/CIR/industry sources.
| Product Category | Typical Range | Max Reported | Source |
|---|---|---|---|
| Shampoo | 0.001–0.1 | 0.5 | CIR Safety Assessment |
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Dye
Flavouring and nutrient
Fragrance
No specific technical function
Regulatory List Membership (4)
EU Restricted for Children (Cosmetics)
IFRA Fragrance Transparency List
EPA Safer Chemical Ingredients List (SCIL)
FDA Substances Added to Food (EAFUS)
Editorial summary
Preliminary editorial summary for CI 19140 — not a computed safety verdict. See the sourced toxicological data above.
Regulatory Flags
azo-dye
fda-certified
eu-permitted
eye-area-permitted
lip-safe
batch-certification-required
hypersensitivity-minority
synthetic-colorant
eu_children_restricted
epa_safer_alternative
ifra_fragrance
fda_food_additive
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to CI 19140 by CAS number or substance name.
Studies
19
Lowest NOAEL
500
Highest NOAEL
5000
Units vary across source rows: mg/kg bw/day, mg/kg
COSMOS DB
ECHA
SCCNFP Opinion
Known Synonyms
1H-Pyrazole-3-carboxylic acid, 4,5-dihydro-5-oxo-1-(4-sulfophenyl)-4-[(4-sulfophenyl)azo]-, trisodium salt
C.I. 19140
Tartrazine
Tartrazine yellow 19140
D&C Yellow 5
A.F. Yellow No. 4
Acid Leather Yellow T
Dye FD and C Yellow No. 5
EINECS 217-699-5
FD & C Yellow No. 5
FD & C Yellow No. 5 tartrazine
FD and C Yellow 5
FD&G Yellow No. 5
Schultz No. 737
1-(4-Sulfophenyl)-4-((4-sulfophenyl)azo)-1H-pyrazole-3-carboxylic
Tartrazine A expo T
Tartrazine C Extra
Tartrazine Extra Pure A
Tartrazine FD & C Yellow #5
Tartrazine FD&C Yellow #5
Chemical Function
Dye
Regulatory Lists
Europe; Personal care - hair coloring
Europe; Personal care - hair coloring
children; Europe; Personal care
children; Europe; Personal care - specialized bath products - bath salts
children; Europe; Personal care - general moisturizing - hand/body lotion
children; Europe; Personal care - body hygiene - body wash
children; Europe; Personal care - hair styling and care - shampoo
children; Europe; Personal care - specialized bath products - bubble bath
children; Europe; Personal care
children; Europe; Personal care
children; Europe; Personal care
Cleaning products and household care; Europe
general_foods
pharmaceutical
Personal care
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
SCIL (9/2019)
active_ingredient; Pesticides
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical and food safety data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL4792247
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
Tartrazine (FD&C Yellow 5)
E Number
E102
ADI
7.5 mg/kg bw
Food Category
colorant
Frequently Asked Questions
Is CI 19140 allowed in the EU?
CI 19140 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does CI 19140 do in cosmetics?
CI 19140 functions as: Colorant. It is classified as a cosmetic ingredient in our database. CAS number: 1934-21-0.
What is the NOAEL for CI 19140?
The NOAEL (No Observed Adverse Effect Level) for CI 19140 is 500 mg/kg bw/day based on a Neurotoxicity study via oral route in rat. A total of 10 study endpoints are available. Source: COSMOS DB.
Is CI 19140 used outside cosmetics?
CI 19140 also appears in industrial chemical safety, pharmaceutical, and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does CI 19140 have different safety status in cosmetics vs industrial chemicals?
CI 19140 is classified GHS Danger (H317, H334) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check CI 19140 compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
Related Ingredients
CI 40800 (Beta-Carotene)
EXCELLENT
Same category
Colorant. Synthetic or naturally deri...
CI 75130 (Beta-Carotene)
EXCELLENT
Same category
Colorant. Synthetic or plant-derived ...
CI 75170 (Guanine)
EXCELLENT
Same category
Colorant. Natural crystalline materia...
CI 77004 (Kaolin)
EXCELLENT
Same category
Colorant. Natural white clay mineral ...
CI 77007 (Ultramarine Blue)
EXCELLENT
Same category
Colorant. Inorganic mineral pigment s...
CI 77019 (Mica)
EXCELLENT
Same category
Colorant; Opacifying Agent; Bulking A...
(AGARICUS BLAZEI FERMENT + GANODERMA LUCIDUM FERMENT + GANODERMA MULTIPILEUM FERMENT) EXTRACT
GOOD
Similar safety
Anti-sebum, Antioxidant, Skin Protecting
(ANGELICA ACUTILOBA/PAEONIA LACTIFLORA/REHMANNIA GLUTINOSA) ROOT/CNIDIUM OFFICINALE RHIZOME EXTRACT
GOOD
Similar safety
Skin Conditioning, Skin Conditioning ...
(ANGELICA ACUTILOBA/PAEONIA LACTIFLORA/REHMANNIA GLUTINOSA/SCUTELLARIA BAICALENSIS) ROOT/(CNIDIUM OFFICINALE/COPTIS CHINENSIS) RHIZOME/GARDENIA JASMINOIDES FRUIT/PHELLODENDRON CHINENSE BARK EXTRACT
GOOD
Similar safety
(ANGELICA GIGAS/GLYCYRRHIZA URALENSIS/REHMANNIA GLUTINOSA ROOT)/ANGELICA GIGAS STEM/CARTHAMUS TINCTORIUS FLOWER/(CARTHAMUS TINCTORIUS/PRUNUS PERSICA SEED)PORIA COCOS WATER
GOOD
Similar safety
Humectant, Skin Conditioning, Skin Pr...
(ANGELICA KEISKEI/CHRYSANTHEMUM ZAWADSKII) LEAF/STEM/CINNAMOMUM CASSIA BARK/TRICHOSANTES KIRILOWII FRUIT/ULMUS DAVIDIANA BARK/ROOT/(PAEONIA JAPONICA/BUPLEURUM FALCATUM/POLYGALA TENUIFOLIA ROOT)/VISCUS ALBUM STEM EXTRACT
GOOD
Similar safety
Anti-seborrheic, Anti-sebum, Antioxid...
(APPLE/CITRUS JUNOS/LENTIL/PEAR/PUMPKIN/STRAWBERRY/TOMATO FRUIT)/CORN KERNEL/(ARCTIUM LAPPA/BRASSICA OLERACEA ACEPHALA/CABBAGE/CAMELLIA SINENSIS/MORINGA OLEIFERA/RADISH/SPINACH LEAF)/(SORGHUM BICOLOR LEAF/STEM)/OAT MEAL/POTATO PULP/(CARROT/NELUMBO NUCIFERA/RADISH/WILD YAM ROOT)/(AMARANTHUS HYPOCHONDRIACUS/CASHEW/CICER ARIETINUM/COIX LACRYMA-JOBI MA-YUEN /MACADAMIA TERNIFOLIA/PHASEOLUS ANGULARIS/PISTACIA VERA/RHYNCHOSIA NULUBILIS/RICE/SESAME/SETARIA ITALICA/SOYBEAN/SWEET ALMOND/WHEAT SEED)/HORDEUM VULGARE SPROUT/CYPERUS ESCULENTUS TUBER/ARTEMISIA PRINCEPS/BROCCOLI/CHENOPODIUM QUINOA/ENTEROMORPHA COMPRESSA/HORDEUM VULGARE/IPOMOEA BATATAS/LAMINARIA JAPONICA/LENTINUS EDODES/PLEUROTUS OSTREATUS/PORPHYRA TENERA/UNDARIA PINNATIFIDA EXTRACT
GOOD
Similar safety
Antioxidant
Acid Yellow 23
GOOD
Chemical family
Colorant (monoazo dye; Tartrazine)
CI 14270
GOOD
Chemical family
Colorant
CI 19140 (Tartrazine)
GOOD
Chemical family
Colorant, Hair Dyeing Agent
Is CI 19140 in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for CI 19140 in your formulation.