Is Acryloyl Morpholine safe in cosmetics?
Acryloyl Morpholine has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
MODERATE
Cosmetic Ingredient
Acryloyl Morpholine
Also known as: Morpholine, 4-(1-oxo-2-propenyl)-, 4-(1-Oxo-2-propenyl)morpholine, 1-(Morpholin-4-yl)prop-2-en-1-one, 2-Propen-1-one, 1-(4-morpholinyl)-, UNII-K0Y58P61JA
INCI: ACRYLOYL MORPHOLINE
Acryloyl Morpholine (CAS 5117-12-4) is a cosmetic cosmetic ingredient functioning as Hair conditioning, film forming. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
Cross-Vertical Regulatory Divergence
Acryloyl Morpholine is classified GHS Danger (H302, H317, H318, H331, H373, H335) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu status; Chemicals: ghs classifications.signal word/hazard statement code
Function
Hair conditioning, film forming
Editorial assessment
MODERATE
Preliminary editorial note — not a computed safety verdict.
Chemistry & Identifiers
IUPAC Name
1-morpholin-4-ylprop-2-en-1-one
InChIKey
XLPJNCYCZORXHG-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
No specific FDA restriction; no CIR review
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Acryloyl Morpholine.
Calculate MoS for your specific formulation with the MoS Calculator.
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Danger
Pictograms
Harmful / IrritantHealth HazardCorrosive
Hazard Class and Category
Acute Tox. 4 *; STOT RE 2 *; Eye Dam. 1; Skin Sens. 1
Hazard Statements
- H302 Harmful if swallowed
- H373 **
- H318 Causes serious eye damage
- H317 May cause an allergic skin reaction
Inserted via ATP: CLP00
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Plasticizer
Editorial summary
Preliminary editorial summary for Acryloyl Morpholine — not a computed safety verdict. See the sourced toxicological data above.
Regulatory Flags
potential-allergen
Known Synonyms
Morpholine, 4-(1-oxo-2-propenyl)-
4-(1-Oxo-2-propenyl)morpholine
1-(Morpholin-4-yl)prop-2-en-1-one
2-Propen-1-one, 1-(4-morpholinyl)-
UNII-K0Y58P61JA
Chemical Function
Plasticizer
Regulatory Lists
Cons electronics mech appliances and machinery; detected; Europe
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3187188
Frequently Asked Questions
Is Acryloyl Morpholine allowed in the EU?
Acryloyl Morpholine EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Acryloyl Morpholine do in cosmetics?
Acryloyl Morpholine functions as: Hair conditioning, film forming. It is classified as a cosmetic ingredient in our database. CAS number: 5117-12-4.
Is Acryloyl Morpholine used outside cosmetics?
Acryloyl Morpholine also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Acryloyl Morpholine have different safety status in cosmetics vs industrial chemicals?
Acryloyl Morpholine is classified GHS Danger (H302, H317, H318, H331, H373, H335) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Acryloyl Morpholine compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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