Adenosine Triphosphate

INCI: ADENOSINE TRIPHOSPHATE

CAS Number
56-65-5
Function
Skin Conditioning Agent – Miscellaneous
Safety Rating
GOOD

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Permitted in cosmetics. CIR Panel concluded safe as used (Sept 2020). Drug use withdrawn per 21 CFR 216.24, but cosmetic use unaffected

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
negligible
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Intradermal ATP induces dose-dependent histamine release, wheal formation, and pain at high concentrations (>180 nmol). Inhalation provokes cough in 80% of subjects and dyspnea in asthmatics — exercise caution in spray/aerosol products

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Concern Level: Moderate

Frequently Asked Questions

Is Adenosine Triphosphate safe in cosmetics?

Intradermal ATP induces dose-dependent histamine release, wheal formation, and pain at high concentrations (>180 nmol). Inhalation provokes cough in 80% of subjects and dyspnea in asthmatics — exercise caution in spray/aerosol products The EU classifies Adenosine Triphosphate as "permitted". Safety rating: GOOD.

Is Adenosine Triphosphate allowed in the EU?

Adenosine Triphosphate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Adenosine Triphosphate do in cosmetics?

Adenosine Triphosphate functions as: Skin Conditioning Agent – Miscellaneous. It is classified as a cosmetic ingredient in our database. CAS number: 56-65-5.

What is the Margin of Safety for Adenosine Triphosphate?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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