Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
3 study endpoints found for Alanine. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 5000 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 20000 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| dose_tested | 5000 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
Expert Verdict
Clean, endogenous amino acid and NMF component with skin and hair conditioning roles. No EU or US restrictions, no concentration limits, full CIR clearance, no safety concerns at any reported use concentration.
Regulatory Flags
Frequently Asked Questions
Is Alanine safe in cosmetics?
Clean, endogenous amino acid and NMF component with skin and hair conditioning roles. No EU or US restrictions, no concentration limits, full CIR clearance, no safety concerns at any reported use concentration. The EU classifies Alanine as "permitted". Safety rating: EXCELLENT. 3 toxicological study endpoint(s) are available in our database.
Is Alanine allowed in the EU?
Alanine EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Alanine do in cosmetics?
Alanine functions as: skin conditioning, hair conditioning, antistatic, fragrance. It is classified as a Humectant in our database. CAS number: 56-41-7.
What is the Margin of Safety for Alanine?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Alanine?
The NOAEL (No Observed Adverse Effect Level) for Alanine is 5000 mg/kg bw/day based on a Short Term Toxicity study via oral route in rat. A total of 3 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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Related Ingredients
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