Is Adipic Acid Dihydrazide safe in cosmetics?
Adipic Acid Dihydrazide has a safety rating of "POOR" in our database. EU status: prohibited. US status: permitted. 1 toxicological study endpoint(s) are available in our database.
Adipic Acid Dihydrazide
Also known as: Hexanedioic acid, dihydrazide, EINECS 213-999-5
INCI: ADIPIC ACID DIHYDRAZIDE
Adipic Acid Dihydrazide (CAS 1071-93-8) is a cosmetic cosmetic ingredient functioning as Cross-linking agent. Reported NOAEL =100 mg/kg bw/day in Rat (ECHA); EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 1071-93-8 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Adipic Acid Dihydrazide is prohibited in EU cosmetics but has active industrial GHS classifications (H317, H411, H320, H361, H400, H410).
Source: Cosmetics: ingredients.eu status; Chemicals: ghs classifications.signal word/hazard statement code
Function
Cross-linking agent
Safety Rating
POOR
Chemistry & Identifiers
IUPAC Name
hexanedihydrazide
InChIKey
IBVAQQYNSHJXBV-UHFFFAOYSA-N
Regulatory Status
EU EU Status
prohibited
US US Status
permitted
US Notes
CIR Expert Panel: Insufficient data to determine safety; no reported cosmetic use at time of evaluation
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Adipic Acid Dihydrazide.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
1 study endpoint found for Adipic Acid Dihydrazide. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =100 mg/kg bw/day | oral | Rat | developmental | ECHA |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Chemical reaction regulator
Deodorizer
Hardener
Humectant
No specific technical function
Processing aids not otherwise specified
Viscosity modifier
Expert Verdict
Expert safety assessment and concern-level summary for Adipic Acid Dihydrazide.
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Adipic Acid Dihydrazide by CAS number or substance name.
Studies
1
Lowest NOAEL
100 mg/kg bw/day
Highest NOAEL
100 mg/kg bw/day
ECHA
Known Synonyms
Hexanedioic acid, dihydrazide
EINECS 213-999-5
Chemical Function
Deodorizer
Processing aids not otherwise specified
No specific technical function
Chemical reaction regulator
Viscosity modifier
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3185968
Frequently Asked Questions
Is Adipic Acid Dihydrazide allowed in the EU?
Adipic Acid Dihydrazide EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Adipic Acid Dihydrazide do in cosmetics?
Adipic Acid Dihydrazide functions as: Cross-linking agent. It is classified as a cosmetic ingredient in our database. CAS number: 1071-93-8.
What is the NOAEL for Adipic Acid Dihydrazide?
The NOAEL (No Observed Adverse Effect Level) for Adipic Acid Dihydrazide is =100 mg/kg bw/day based on a developmental study via oral route in Rat. Source: ECHA.
Is Adipic Acid Dihydrazide used outside cosmetics?
Adipic Acid Dihydrazide also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Adipic Acid Dihydrazide have different safety status in cosmetics vs industrial chemicals?
Adipic Acid Dihydrazide is prohibited in EU cosmetics but has active industrial GHS classifications (H317, H411, H320, H361, H400, H410).
Compliance Tools
Check Adipic Acid Dihydrazide compliance across multiple jurisdictions:
Ingredient Decoder
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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