Alloferon-1

INCI: ALLOFERON-1

CAS Number
478296-76-9 (synthetic antimicrobial peptide, originally isolated from blowfly)
Function
Bleaching (skin lightening), Skin Conditioning – Emollient, Skin Protecting
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Not restricted by FDA; no specific monograph

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
negligible
Sensitization
high

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Immunomodulatory activity with interferon-inducing and NK cell-activating properties raises questions about systemic activity claims versus cosmetic classification; limited dermal penetration mitigates concern but regulatory challenges exist regarding drug-cosmetic borderline in some jurisdictions.

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Concern Level: High

Frequently Asked Questions

Is Alloferon-1 safe in cosmetics?

Immunomodulatory activity with interferon-inducing and NK cell-activating properties raises questions about systemic activity claims versus cosmetic classification; limited dermal penetration mitigates concern but regulatory challenges exist regarding drug-cosmetic borderline in some jurisdictions. The EU classifies Alloferon-1 as "permitted". Safety rating: MODERATE.

Is Alloferon-1 allowed in the EU?

Alloferon-1 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Alloferon-1 do in cosmetics?

Alloferon-1 functions as: Bleaching (skin lightening), Skin Conditioning – Emollient, Skin Protecting. It is classified as a cosmetic ingredient in our database. CAS number: 478296-76-9 (synthetic antimicrobial peptide, originally isolated from blowfly).

What is the Margin of Safety for Alloferon-1?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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