Moderate Cosmetic Ingredient NOAEL Data

Allyl Propionate

INCI: ALLYL PROPIONATE

CAS Number
2408-20-0
Function
Fragrance
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Not specifically restricted by FDA; governed by general cosmetic safety provisions

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
moderate
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

4 study endpoints found for Allyl Propionate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 19.3 mg/kg bw/day oral rat Subchronic COSMOS_DB
NOAEL 18 mg/kg bw/day oral rat oral REACH
NOAEL 15.54 other oral rat oral REACH
NOAEL 14.4 other oral rat oral REACH

Expert Verdict

Free allyl alcohol is a reactive impurity—the primary safety concern. Must be controlled below 0.1% in the ester.

⚠️
Concern Level: Moderate

Regulatory Flags

fragrance-component ifra_fragrance fda_food_additive eu_cosing_listed jecfa_safe

Frequently Asked Questions

Is Allyl Propionate safe in cosmetics?

Free allyl alcohol is a reactive impurity—the primary safety concern. Must be controlled below 0.1% in the ester. The EU classifies Allyl Propionate as "permitted". Safety rating: MODERATE. 4 toxicological study endpoint(s) are available in our database.

Is Allyl Propionate allowed in the EU?

Allyl Propionate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Allyl Propionate do in cosmetics?

Allyl Propionate functions as: Fragrance. It is classified as a cosmetic ingredient in our database. CAS number: 2408-20-0.

What is the Margin of Safety for Allyl Propionate?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Allyl Propionate?

The NOAEL (No Observed Adverse Effect Level) for Allyl Propionate is 19.3 mg/kg bw/day based on a Subchronic study via oral route in rat. A total of 4 study endpoints are available. Source: COSMOS_DB.

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